(R)-N-(4-{4-[(4'-chloro-[1,1'-biphenyl]-2-yl)methyl]piperazin-1-yl}phenyl)-4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl]amino}-3-nitrobenzenesulfonamide

Base Information

Chemical Name:(R)-N-(4-{4-[(4'-chloro-[1,1'-biphenyl]-2-yl)methyl]piperazin-1-yl}phenyl)-4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl]amino}-3-nitrobenzenesulfonamide
CAS No.:1376190-41-8
Molecular Formula:C₄₁H₄₅ClN₆O₄S₂
Molecular Weight:785.431
Hs Code.:

Synonyms:(R)-N-(4-{4-[(4'-chloro-[1,1'-biphenyl]-2-yl)methyl]piperazin-1-yl}phenyl)-4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl]amino}-3-nitrobenzenesulfonamide

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Chemical Property of (R)-N-(4-{4-[(4'-chloro-[1,1'-biphenyl]-2-yl)methyl]piperazin-1-yl}phenyl)-4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl]amino}-3-nitrobenzenesulfonamide

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Technology Process of (R)-N-(4-{4-[(4'-chloro-[1,1'-biphenyl]-2-yl)methyl]piperazin-1-yl}phenyl)-4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl]amino}-3-nitrobenzenesulfonamide

There total 5 articles about (R)-N-(4-{4-[(4'-chloro-[1,1'-biphenyl]-2-yl)methyl]piperazin-1-yl}phenyl)-4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl]amino}-3-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1376190-51-0
(R)-4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl]amino}-3-nitro-N-[4-(piperazin-1-yl)phenyl]benzenesulfonamide

: 153850-83-0
4'-chlorobiphenyl-2-carboxaldehyde

: 1376190-41-8
(R)-N-(4-{4-[(4'-chloro-[1,1'-biphenyl]-2-yl)methyl]piperazin-1-yl}phenyl)-4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl]amino}-3-nitrobenzenesulfonamide

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/jm300178u

Reference yield:

: 1376191-12-6
t-butyl 4-[4-(4-fluoro-3-nitrophenylsulfonamido)phenyl]piperazine-1-carboxylate

: 1376190-41-8
(R)-N-(4-{4-[(4'-chloro-[1,1'-biphenyl]-2-yl)methyl]piperazin-1-yl}phenyl)-4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl]amino}-3-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / Inert atmosphere

1.2: 5 h / Inert atmosphere

2.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 24 h / 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm300178u

Reference yield:

: 170911-92-9
4-(4-aminophenyl)-1-t-butyloxycarbonylpiperazine

: 1376190-41-8
(R)-N-(4-{4-[(4'-chloro-[1,1'-biphenyl]-2-yl)methyl]piperazin-1-yl}phenyl)-4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl]amino}-3-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 0.5 h / 0 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / Inert atmosphere

2.2: 5 h / Inert atmosphere

3.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 24 h / 20 °C / Inert atmosphere

With pyridine; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm300178u