N-4-(1-(2-nitrophenylsulfonamido)cyclobutanecarboxyamido)adamantane-1-carboxyamide

Base Information

Chemical Name:N-4-(1-(2-nitrophenylsulfonamido)cyclobutanecarboxyamido)adamantane-1-carboxyamide
CAS No.:1422025-87-3
Molecular Formula:C₂₂H₂₈N₄O₆S
Molecular Weight:476.554
Hs Code.:

Synonyms:N-4-(1-(2-nitrophenylsulfonamido)cyclobutanecarboxyamido)adamantane-1-carboxyamide

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Chemical Property of N-4-(1-(2-nitrophenylsulfonamido)cyclobutanecarboxyamido)adamantane-1-carboxyamide

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Technology Process of N-4-(1-(2-nitrophenylsulfonamido)cyclobutanecarboxyamido)adamantane-1-carboxyamide

There total 9 articles about N-4-(1-(2-nitrophenylsulfonamido)cyclobutanecarboxyamido)adamantane-1-carboxyamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1422027-34-6
4-(1-(2-nitrophenylsulfonamido)cyclobutanecarboxyamido)adamantane-1-carboxylic acid

: 1422025-87-3
N-4-(1-(2-nitrophenylsulfonamido)cyclobutanecarboxyamido)adamantane-1-carboxyamide

Guidance literature:: 4-(1-(2-nitrophenylsulfonamido)cyclobutanecarboxyamido)adamantane-1-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 0.5h;

With ammonium hydroxide; In dichloromethane; water; at 20 ℃; for 12h;

Reference yield:

: 56674-87-4
4-oxoadamantane-1-carboxylic acid

: 1422025-87-3
N-4-(1-(2-nitrophenylsulfonamido)cyclobutanecarboxyamido)adamantane-1-carboxyamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonia; palladium 10% on activated carbon; hydrogen / methanol / 12 h

2.1: acetyl chloride / 12 h / 20 - 45 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 12 h / 20 °C

4.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 12 h / 20 °C

4.2: pH 2 - 3

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.5 h

5.2: 12 h / 20 °C

With dmap; lithium hydroxide monohydrate; palladium 10% on activated carbon; ammonia; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; acetyl chloride; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 1057343-95-9,898265-47-9
4-amino-adamantane-1-carboxylic acid

: 1422025-87-3
N-4-(1-(2-nitrophenylsulfonamido)cyclobutanecarboxyamido)adamantane-1-carboxyamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetyl chloride / 12 h / 20 - 45 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 12 h / 20 °C

3.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 12 h / 20 °C

3.2: pH 2 - 3

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.5 h

4.2: 12 h / 20 °C

With dmap; lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; acetyl chloride; In tetrahydrofuran; methanol; dichloromethane; water;