tert-Butyl-[(E)-(S)-1-[(S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-3-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-allyloxy]-dimethyl-silane

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Chemical Name:tert-Butyl-[(E)-(S)-1-[(S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-3-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-allyloxy]-dimethyl-silane
CAS No.:856410-57-6
Molecular Formula:C₂₆H₄₀O₅Si
Molecular Weight:460.686
Hs Code.:

Synonyms:tert-Butyl-[(E)-(S)-1-[(S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-3-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-allyloxy]-dimethyl-silane

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Chemical Property of tert-Butyl-[(E)-(S)-1-[(S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-3-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-allyloxy]-dimethyl-silane

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Technology Process of tert-Butyl-[(E)-(S)-1-[(S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-3-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-allyloxy]-dimethyl-silane

There total 10 articles about tert-Butyl-[(E)-(S)-1-[(S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-3-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-allyloxy]-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 856410-42-9
(E)-(S)-1-[(S)-2-(4-Methoxy-phenyl)-[1,3]dioxan-4-yl]-3-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-prop-2-en-1-ol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 856410-57-6
tert-Butyl-[(E)-(S)-1-[(S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-3-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-allyloxy]-dimethyl-silane

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1002/anie.200500029

Reference yield:

: (2E,5Z)-(S)-1-{(4S,5S)-5-[2-(4-Methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-5-methyl-hepta-2,5-diene-1,7-diol

: 856410-57-6
tert-Butyl-[(E)-(S)-1-[(S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-3-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-allyloxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / PdCl₂(CH₃CN)2 / tetrahydrofuran / 3 h / 0 °C

2: 89 percent / HCl / methanol / 20 °C

3: 87 percent / DDQ / CH₂Cl₂ / 0 °C

4: 90 percent / imidazole / dimethylformamide / 20 °C

With 1H-imidazole; hydrogenchloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; dichloro bis(acetonitrile) palladium(II); In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.200500029

Reference yield:

: Carbonic acid (2E,5Z)-(S)-7-hydroxy-1-{(4R,5S)-5-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-5-methyl-hepta-2,5-dienyl ester methyl ester

: 856410-57-6
tert-Butyl-[(E)-(S)-1-[(S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-3-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-allyloxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: 59 percent / neocuproine / Pd₂(dba)3 / toluene / 80 °C

2: 89 percent / HCl / methanol / 20 °C

3: 87 percent / DDQ / CH₂Cl₂ / 0 °C

4: 90 percent / imidazole / dimethylformamide / 20 °C

With 1H-imidazole; hydrogenchloride; 2.9-dimethyl-1,10-phenanthroline; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.200500029