2-(4-benzyloxy-2,6-dichloro-benzyl)-2-(2,2-dimethoxy-ethyl)-malonic acid diethyl ester

Base Information

Chemical Name:2-(4-benzyloxy-2,6-dichloro-benzyl)-2-(2,2-dimethoxy-ethyl)-malonic acid diethyl ester
CAS No.:955373-57-6
Molecular Formula:C₂₅H₃₀Cl₂O₇
Molecular Weight:513.415
Hs Code.:

Synonyms:2-(4-benzyloxy-2,6-dichloro-benzyl)-2-(2,2-dimethoxy-ethyl)-malonic acid diethyl ester

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Chemical Property of 2-(4-benzyloxy-2,6-dichloro-benzyl)-2-(2,2-dimethoxy-ethyl)-malonic acid diethyl ester

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Technology Process of 2-(4-benzyloxy-2,6-dichloro-benzyl)-2-(2,2-dimethoxy-ethyl)-malonic acid diethyl ester

There total 1 articles about 2-(4-benzyloxy-2,6-dichloro-benzyl)-2-(2,2-dimethoxy-ethyl)-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 886616-14-4
5-benzyloxy-2-bromomethyl-1,3-dichloro-benzene

: 955373-57-6
2-(4-benzyloxy-2,6-dichloro-benzyl)-2-(2,2-dimethoxy-ethyl)-malonic acid diethyl ester

Guidance literature:: 2-(2,2-dimethoxyethyl)malonic acid diethyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.25h;

5-benzyloxy-2-bromomethyl-1,3-dichloro-benzene; In tetrahydrofuran;

Reference yield: 80.0%

: 955373-57-6
2-(4-benzyloxy-2,6-dichloro-benzyl)-2-(2,2-dimethoxy-ethyl)-malonic acid diethyl ester

: 955373-58-7
2-(4-benzyloxy-2,6-dichloro-benzyl)-2-(2-oxo-ethyl)-malonicacid diethyl ester

Guidance literature:: With formic acid; In acetone; for 24h;

Reference yield:

: 955373-57-6
2-(4-benzyloxy-2,6-dichloro-benzyl)-2-(2,2-dimethoxy-ethyl)-malonic acid diethyl ester

: trifluoromethanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(3-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-3H-benzimidazol-5-yl)-pyrrolidin-3-[R]-ylmethyl]-phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: formic acid / acetone / 24 h

2: sodium cyanoborohydride / methanol / 2 h / 50 °C

3: Resolution of racemate

4: hydrogen / palladium dihydroxide / methanol; ethyl acetate / 20 - 40 °C

5: pyridine / dichloromethane / -78 °C

With pyridine; formic acid; hydrogen; sodium cyanoborohydride; palladium dihydroxide; In methanol; dichloromethane; ethyl acetate; acetone;