trimethyl[[4-[(trifluoromethyl)sulfonyl]phenyl]ethynyl]silane

Base Information

• Chemical Name: trimethyl[[4-[(trifluoromethyl)sulfonyl]phenyl]ethynyl]silane
• CAS No.: 933038-06-3
• Molecular Formula: C₁₂H₁₃F₃O₂SSi
• Molecular Weight: 306.381
• Mol file: 933038-06-3.mol

Synonyms:trimethyl[[4-[(trifluoromethyl)sulfonyl]phenyl]ethynyl]silane

Chemical Property of trimethyl[[4-[(trifluoromethyl)sulfonyl]phenyl]ethynyl]silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of trimethyl[[4-[(trifluoromethyl)sulfonyl]phenyl]ethynyl]silane

There total 3 articles about trimethyl[[4-[(trifluoromethyl)sulfonyl]phenyl]ethynyl]silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-bromo-4-(trifluoromethylsulfonyl)benzene (312-20-9) + trimethylsilylacetylene (1066-54-2) → trimethyl[[4-[(trifluoromethyl)sulfonyl]phenyl]ethynyl]silane (933038-06-3)

Guidance literature:

With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; at 40 ℃; for 3h;

DOI:10.1002/chem.200600689

Reference yield:

1-bromo-4-(trifluoromethyl)thiobenzene (333-47-1) → trimethyl[[4-[(trifluoromethyl)sulfonyl]phenyl]ethynyl]silane (933038-06-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / aq. H₂O₂ / acetic acid / 3 h / Heating

2: 88 percent / Et₃N / Pd(PPh₃)2Cl₂; CuI / 3 h / 40 °C

With dihydrogen peroxide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In acetic acid; 2: Sonogashira coupling;

DOI:10.1002/chem.200600689

Reference yield:

para-bromobenzenethiol (106-53-6) → trimethyl[[4-[(trifluoromethyl)sulfonyl]phenyl]ethynyl]silane (933038-06-3)

Guidance literature:

Multi-step reaction with 3 steps

2: H₂O₂

3: Cu/Pd

With copper-palladium; dihydrogen peroxide;

upstream raw materials:

1-bromo-4-(trifluoromethylsulfonyl)benzene

trimethylsilylacetylene

1-bromo-4-(trifluoromethyl)thiobenzene

para-bromobenzenethiol

Downstream raw materials:

1-ethynyl-4-[(trifluoromethyl)sulfonyl]benzene