(1'R,2'S,4'S,5'S)-1-[(bis-(4-methoxyphenyl)-phenylmethoxy)methyl]-4-(2-iodo-6-methylaminopurin-9-yl)-bicyclo[3.1.0]hexan-2-ol

Base Information

Chemical Name:(1'R,2'S,4'S,5'S)-1-[(bis-(4-methoxyphenyl)-phenylmethoxy)methyl]-4-(2-iodo-6-methylaminopurin-9-yl)-bicyclo[3.1.0]hexan-2-ol
CAS No.:945565-67-3
Molecular Formula:C₃₄H₃₄IN₅O₄
Molecular Weight:703.58
Hs Code.:

Synonyms:(1'R,2'S,4'S,5'S)-1-[(bis-(4-methoxyphenyl)-phenylmethoxy)methyl]-4-(2-iodo-6-methylaminopurin-9-yl)-bicyclo[3.1.0]hexan-2-ol

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Chemical Property of (1'R,2'S,4'S,5'S)-1-[(bis-(4-methoxyphenyl)-phenylmethoxy)methyl]-4-(2-iodo-6-methylaminopurin-9-yl)-bicyclo[3.1.0]hexan-2-ol

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Technology Process of (1'R,2'S,4'S,5'S)-1-[(bis-(4-methoxyphenyl)-phenylmethoxy)methyl]-4-(2-iodo-6-methylaminopurin-9-yl)-bicyclo[3.1.0]hexan-2-ol

There total 6 articles about (1'R,2'S,4'S,5'S)-1-[(bis-(4-methoxyphenyl)-phenylmethoxy)methyl]-4-(2-iodo-6-methylaminopurin-9-yl)-bicyclo[3.1.0]hexan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 945565-66-2
(1'R,2'S,4'S,5'S)-1-hydroxymethyl-4-(2-iodo-6-methylaminopurin-9-yl)-bicyclo[3.1.0]hexan-2-ol

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 945565-67-3
(1'R,2'S,4'S,5'S)-1-[(bis-(4-methoxyphenyl)-phenylmethoxy)methyl]-4-(2-iodo-6-methylaminopurin-9-yl)-bicyclo[3.1.0]hexan-2-ol

Guidance literature:: With dmap; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1021/jm0700971

Reference yield:

: 945565-65-1
(1'R,2'S,4'S,5'S)-acetic acid 1-acetoxymethyl-4-(6-chloro-2-iodopurin-9-yl)-bicyclo[3.1.0]hex-2-yl ester

: 945565-67-3
(1'R,2'S,4'S,5'S)-1-[(bis-(4-methoxyphenyl)-phenylmethoxy)methyl]-4-(2-iodo-6-methylaminopurin-9-yl)-bicyclo[3.1.0]hexan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 6.5 h / 20 °C

2: 15 mg / aq. NaOH / methanol / 20 °C

3: 92 percent / 4-dimethylaminopyridine / dimethylformamide / 24 h / 20 °C

With dmap; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0700971

Reference yield:

: C₁₇H₂₀IN₅O₄

: 945565-67-3
(1'R,2'S,4'S,5'S)-1-[(bis-(4-methoxyphenyl)-phenylmethoxy)methyl]-4-(2-iodo-6-methylaminopurin-9-yl)-bicyclo[3.1.0]hexan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 15 mg / aq. NaOH / methanol / 20 °C

2: 92 percent / 4-dimethylaminopyridine / dimethylformamide / 24 h / 20 °C

With dmap; sodium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0700971