(1'R,2'S,4'S,5'S)-phosphoric acid 1-[(bis-(4-methoxyphenyl)-phenylmethoxy)methyl]-4-(2-iodo-6-methylaminopurin-9-yl)-bicyclo[3.1.0]hex-2-yl ester di-tert-butyl ester

Base Information

Chemical Name:(1'R,2'S,4'S,5'S)-phosphoric acid 1-[(bis-(4-methoxyphenyl)-phenylmethoxy)methyl]-4-(2-iodo-6-methylaminopurin-9-yl)-bicyclo[3.1.0]hex-2-yl ester di-tert-butyl ester
CAS No.:945565-68-4
Molecular Formula:C₄₂H₅₁IN₅O₇P
Molecular Weight:895.774
Hs Code.:

(1'R,2'S,4'S,5'S)-phosphoric acid 1-[(bis-(4-methoxyphenyl)-phenylmethoxy)methyl]-4-(2-iodo-6-methylaminopurin-9-yl)-bicyclo[3.1.0]hex-2-yl ester di-tert-butyl ester

Synonyms:(1'R,2'S,4'S,5'S)-phosphoric acid 1-[(bis-(4-methoxyphenyl)-phenylmethoxy)methyl]-4-(2-iodo-6-methylaminopurin-9-yl)-bicyclo[3.1.0]hex-2-yl ester di-tert-butyl ester

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Chemical Property of (1'R,2'S,4'S,5'S)-phosphoric acid 1-[(bis-(4-methoxyphenyl)-phenylmethoxy)methyl]-4-(2-iodo-6-methylaminopurin-9-yl)-bicyclo[3.1.0]hex-2-yl ester di-tert-butyl ester

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Technology Process of (1'R,2'S,4'S,5'S)-phosphoric acid 1-[(bis-(4-methoxyphenyl)-phenylmethoxy)methyl]-4-(2-iodo-6-methylaminopurin-9-yl)-bicyclo[3.1.0]hex-2-yl ester di-tert-butyl ester

There total 7 articles about (1'R,2'S,4'S,5'S)-phosphoric acid 1-[(bis-(4-methoxyphenyl)-phenylmethoxy)methyl]-4-(2-iodo-6-methylaminopurin-9-yl)-bicyclo[3.1.0]hex-2-yl ester di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 945565-67-3
(1'R,2'S,4'S,5'S)-1-[(bis-(4-methoxyphenyl)-phenylmethoxy)methyl]-4-(2-iodo-6-methylaminopurin-9-yl)-bicyclo[3.1.0]hexan-2-ol

: 117924-33-1
di-tert-butyl N,N-diethylphosphoramidite

: 945565-68-4
(1'R,2'S,4'S,5'S)-phosphoric acid 1-[(bis-(4-methoxyphenyl)-phenylmethoxy)methyl]-4-(2-iodo-6-methylaminopurin-9-yl)-bicyclo[3.1.0]hex-2-yl ester di-tert-butyl ester

Guidance literature:: (1'R,2'S,4'S,5'S)-1-[(bis-(4-methoxyphenyl)-phenylmethoxy)methyl]-4-(2-iodo-6-methylaminopurin-9-yl)-bicyclo[3.1.0]hexan-2-ol; di-tert-butyl N,N-diethylphosphoramidite; With 1H-tetrazole; In tetrahydrofuran; at 20 ℃; for 3.5h;

With 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; at 20 ℃; for 0.5h; Further stages.;
DOI:10.1021/jm0700971

Reference yield:

: C₁₆H₁₈ClN₅O₄

: 945565-68-4
(1'R,2'S,4'S,5'S)-phosphoric acid 1-[(bis-(4-methoxyphenyl)-phenylmethoxy)methyl]-4-(2-iodo-6-methylaminopurin-9-yl)-bicyclo[3.1.0]hex-2-yl ester di-tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 20.0 mg / tert-butyl nitrite; diiodomethane / acetonitrile / 3 h / 80 °C

2.1: tetrahydrofuran / 6.5 h / 20 °C

3.1: 15 mg / aq. NaOH / methanol / 20 °C

4.1: 92 percent / 4-dimethylaminopyridine / dimethylformamide / 24 h / 20 °C

5.1: 1H-tetrazole / tetrahydrofuran / 3.5 h / 20 °C

5.2: 21 percent / m-CPBA / tetrahydrofuran; CH₂Cl₂ / 0.5 h / 20 °C

With 1H-tetrazole; dmap; sodium hydroxide; tert.-butylnitrite; diiodomethane; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm0700971

Reference yield:

: 945565-65-1
(1'R,2'S,4'S,5'S)-acetic acid 1-acetoxymethyl-4-(6-chloro-2-iodopurin-9-yl)-bicyclo[3.1.0]hex-2-yl ester

: 945565-68-4
(1'R,2'S,4'S,5'S)-phosphoric acid 1-[(bis-(4-methoxyphenyl)-phenylmethoxy)methyl]-4-(2-iodo-6-methylaminopurin-9-yl)-bicyclo[3.1.0]hex-2-yl ester di-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 6.5 h / 20 °C

2.1: 15 mg / aq. NaOH / methanol / 20 °C

3.1: 92 percent / 4-dimethylaminopyridine / dimethylformamide / 24 h / 20 °C

4.1: 1H-tetrazole / tetrahydrofuran / 3.5 h / 20 °C

4.2: 21 percent / m-CPBA / tetrahydrofuran; CH₂Cl₂ / 0.5 h / 20 °C

With 1H-tetrazole; dmap; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0700971