N-(2-(N,N-diethylamino)ethyl)-6-(3-(1-(2-iodophenyl)-2.5.8.11-tetraoxatridecan-13-yl)ureido)quinoxaline-2-carboxamide

Base Information

Chemical Name:N-(2-(N,N-diethylamino)ethyl)-6-(3-(1-(2-iodophenyl)-2.5.8.11-tetraoxatridecan-13-yl)ureido)quinoxaline-2-carboxamide
CAS No.:1569294-09-2
Molecular Formula:C₃₁H₄₃IN₆O₆
Molecular Weight:722.624
Hs Code.:

Synonyms:N-(2-(N,N-diethylamino)ethyl)-6-(3-(1-(2-iodophenyl)-2.5.8.11-tetraoxatridecan-13-yl)ureido)quinoxaline-2-carboxamide

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Chemical Property of N-(2-(N,N-diethylamino)ethyl)-6-(3-(1-(2-iodophenyl)-2.5.8.11-tetraoxatridecan-13-yl)ureido)quinoxaline-2-carboxamide

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Technology Process of N-(2-(N,N-diethylamino)ethyl)-6-(3-(1-(2-iodophenyl)-2.5.8.11-tetraoxatridecan-13-yl)ureido)quinoxaline-2-carboxamide

There total 6 articles about N-(2-(N,N-diethylamino)ethyl)-6-(3-(1-(2-iodophenyl)-2.5.8.11-tetraoxatridecan-13-yl)ureido)quinoxaline-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1569294-06-9
4-nitrophenyl (2-((2-(N,N-diethylamino)ethyl)carbomoyl)quinoxalin-6-yl)carbamate hydrochloride

: 1569294-04-7
1-(2-iodophenyl)-2,5,8,11-tetraoxatridecan-13-amine

: 1569294-09-2
N-(2-(N,N-diethylamino)ethyl)-6-(3-(1-(2-iodophenyl)-2.5.8.11-tetraoxatridecan-13-yl)ureido)quinoxaline-2-carboxamide

Guidance literature:: 4-nitrophenyl (2-((2-(N,N-diethylamino)ethyl)carbomoyl)quinoxalin-6-yl)carbamate hydrochloride; With dmap; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

1-(2-iodophenyl)-2,5,8,11-tetraoxatridecan-13-amine; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/ml400468x

Reference yield:

: 1569294-05-8
C₁₅H₂₁N₅O

: 1569294-09-2
N-(2-(N,N-diethylamino)ethyl)-6-(3-(1-(2-iodophenyl)-2.5.8.11-tetraoxatridecan-13-yl)ureido)quinoxaline-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: dmap / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2.2: 4 h / 20 °C / Inert atmosphere

With pyridine; dmap; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ml400468x

Reference yield:

: 40400-13-3
2-Iodobenzyl bromide

: 1569294-09-2
N-(2-(N,N-diethylamino)ethyl)-6-(3-(1-(2-iodophenyl)-2.5.8.11-tetraoxatridecan-13-yl)ureido)quinoxaline-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 20 h / 0 - 20 °C / Inert atmosphere

2.1: 1H-imidazole; triphenylphosphine; iodine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

3.1: N,N-dimethyl-formamide / 18 h / 30 °C / Inert atmosphere

4.1: hydrazine / ethanol / 18 h / 30 °C / Inert atmosphere

5.1: dmap / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

5.2: 4 h / 20 °C / Inert atmosphere

With 1H-imidazole; dmap; iodine; sodium hydride; triphenylphosphine; hydrazine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 3.1: |Gabriel Amine Synthesis / 4.1: |Gabriel Amine Synthesis;
DOI:10.1021/ml400468x