2-methyl-5-(3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-3,4-dihydroquinolin-1(2H)-yl)benzoic acid hydrochloride

Base Information

Chemical Name:2-methyl-5-(3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-3,4-dihydroquinolin-1(2H)-yl)benzoic acid hydrochloride
CAS No.:1574000-25-1
Molecular Formula:C₃₀H₃₀N₂O₂*ClH
Molecular Weight:487.041
Hs Code.:

Synonyms:2-methyl-5-(3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-3,4-dihydroquinolin-1(2H)-yl)benzoic acid hydrochloride

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Chemical Property of 2-methyl-5-(3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-3,4-dihydroquinolin-1(2H)-yl)benzoic acid hydrochloride

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Technology Process of 2-methyl-5-(3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-3,4-dihydroquinolin-1(2H)-yl)benzoic acid hydrochloride

There total 6 articles about 2-methyl-5-(3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-3,4-dihydroquinolin-1(2H)-yl)benzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.6%

: methyl 2-methyl-5-(3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-3,4-dihydroquinolin-1(2H)-yl)benzoate

: 1574000-25-1
2-methyl-5-(3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-3,4-dihydroquinolin-1(2H)-yl)benzoic acid hydrochloride

Guidance literature:: methyl 2-methyl-5-(3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-3,4-dihydroquinolin-1(2H)-yl)benzoate; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 80 ℃; for 5h;

With hydrogenchloride; In tetrahydrofuran; methanol; diethyl ether; for 0.166667h;

Reference yield:

: 53951-84-1
methyl quinolone-3-carboxylate

: 1574000-25-1
2-methyl-5-(3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-3,4-dihydroquinolin-1(2H)-yl)benzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium cyanoborohydride; hydrogenchloride; methanol / 1,4-dioxane / 16 h / 20 °C / pH 4 - 5

2.1: trimethylaluminum / toluene / 0.75 h / 55 °C

2.2: 20 h / 55 - 110 °C

3.1: dimethylsulfide borane complex / tetrahydrofuran / 7 h / 0 - 70 °C

3.2: 1 h / 90 °C

4.1: caesium carbonate / toluene / 0.17 h / 20 °C / Inert atmosphere; Sealed tube

4.2: Inert atmosphere; Sealed tube; Reflux

5.1: lithium hydroxide; water / tetrahydrofuran; methanol / 5 h / 80 °C

5.2: 0.17 h

With hydrogenchloride; methanol; dimethylsulfide borane complex; water; trimethylaluminum; sodium cyanoborohydride; caesium carbonate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; toluene;

Reference yield:

: 1573997-70-2
N-((R)-1-(naphthalen-1-yl)ethyl)-1,2,3,4-tetrahydroquinoline-3-carboxamide

: 1574000-25-1
2-methyl-5-(3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-3,4-dihydroquinolin-1(2H)-yl)benzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 7 h / 0 - 70 °C

1.2: 1 h / 90 °C

2.1: caesium carbonate / toluene / 0.17 h / 20 °C / Inert atmosphere; Sealed tube

2.2: Inert atmosphere; Sealed tube; Reflux

3.1: lithium hydroxide; water / tetrahydrofuran; methanol / 5 h / 80 °C

3.2: 0.17 h

With dimethylsulfide borane complex; water; caesium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; toluene;