tert-butyl trans-4a-(2,3-dimethoxyphenyl)-1,6-dioxo-2-methyl-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-7-carboxylate

Base Information

Chemical Name:tert-butyl trans-4a-(2,3-dimethoxyphenyl)-1,6-dioxo-2-methyl-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-7-carboxylate
CAS No.:81012-12-6
Molecular Formula:C₂₃H₃₁NO₆
Molecular Weight:417.502
Hs Code.:

Synonyms:tert-butyl trans-4a-(2,3-dimethoxyphenyl)-1,6-dioxo-2-methyl-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-7-carboxylate

Suppliers and Price of tert-butyl trans-4a-(2,3-dimethoxyphenyl)-1,6-dioxo-2-methyl-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-7-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl trans-4a-(2,3-dimethoxyphenyl)-1,6-dioxo-2-methyl-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-7-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl trans-4a-(2,3-dimethoxyphenyl)-1,6-dioxo-2-methyl-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-7-carboxylate

There total 3 articles about tert-butyl trans-4a-(2,3-dimethoxyphenyl)-1,6-dioxo-2-methyl-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 81012-11-5
tert-butyl 4-(2,3-dimethoxyphenyl)-4-<4-(1-methyl-3-methylene-2-oxopiperidinyl)>-3-oxobutyrate

: 81012-12-6
tert-butyl trans-4a-(2,3-dimethoxyphenyl)-1,6-dioxo-2-methyl-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-7-carboxylate

Guidance literature:: sodium methylate; In methanol; for 20h; Ambient temperature;
DOI:10.1021/jo00349a006

Reference yield:

: 79619-11-7
4-(Carboxymethyl)-4-(2,3-dimethoxyphenyl)-1-methyl-3-methylene-2-piperidinone

: 81012-12-6
tert-butyl trans-4a-(2,3-dimethoxyphenyl)-1,6-dioxo-2-methyl-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / CH₂Cl₂ / 9.5 h / Ambient temperature

2: 1.) isopropylmagnesium bromide / 1.) THF, RT, 4 h, and reflux, 45 min, 2.) THF, RT, 3 d

3: 98 percent / NaOMe / methanol / 20 h / Ambient temperature

With isopropylmagnesium bromide; sodium methylate; In methanol; dichloromethane;
DOI:10.1021/jo00349a006

Reference yield:

: 81012-10-4
imidazolide of 4-(carboxymethyl)-4-(2,3-dimethoxyphenyl)-1-methyl-3-methylene-2-piperidinone

: 81012-12-6
tert-butyl trans-4a-(2,3-dimethoxyphenyl)-1,6-dioxo-2-methyl-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-7-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) isopropylmagnesium bromide / 1.) THF, RT, 4 h, and reflux, 45 min, 2.) THF, RT, 3 d

2: 98 percent / NaOMe / methanol / 20 h / Ambient temperature

With isopropylmagnesium bromide; sodium methylate; In methanol;
DOI:10.1021/jo00349a006