imidazolide of 4-(carboxymethyl)-4-(2,3-dimethoxyphenyl)-1-methyl-3-methylene-2-piperidinone

Base Information

Chemical Name:imidazolide of 4-(carboxymethyl)-4-(2,3-dimethoxyphenyl)-1-methyl-3-methylene-2-piperidinone
CAS No.:81012-10-4
Molecular Formula:C₂₀H₂₃N₃O₄
Molecular Weight:369.42
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of imidazolide of 4-(carboxymethyl)-4-(2,3-dimethoxyphenyl)-1-methyl-3-methylene-2-piperidinone

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Technology Process of imidazolide of 4-(carboxymethyl)-4-(2,3-dimethoxyphenyl)-1-methyl-3-methylene-2-piperidinone

There total 1 articles about imidazolide of 4-(carboxymethyl)-4-(2,3-dimethoxyphenyl)-1-methyl-3-methylene-2-piperidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 79619-11-7
4-(Carboxymethyl)-4-(2,3-dimethoxyphenyl)-1-methyl-3-methylene-2-piperidinone

: 530-62-1
1,1'-carbonyldiimidazole

: 81012-10-4
imidazolide of 4-(carboxymethyl)-4-(2,3-dimethoxyphenyl)-1-methyl-3-methylene-2-piperidinone

Guidance literature:: In dichloromethane; for 9.5h; Ambient temperature;
DOI:10.1021/jo00349a006

Reference yield: 96.0%

: 67-56-1
methanol

: 81012-10-4
imidazolide of 4-(carboxymethyl)-4-(2,3-dimethoxyphenyl)-1-methyl-3-methylene-2-piperidinone

: 79619-07-1
4-<(methoxycarbonyl)methyl>-4-(2,3-dimethoxyphenyl)-1-methyl-3-methylene-2-piperidinone

Guidance literature:: With sodium methylate; for 21h; Ambient temperature;
DOI:10.1021/jo00349a006

Reference yield:

: 81012-10-4
imidazolide of 4-(carboxymethyl)-4-(2,3-dimethoxyphenyl)-1-methyl-3-methylene-2-piperidinone

: 81012-15-9
trans-4a-(2,3-dimethoxyphenyl)-2-methyl-6-oxo-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) isopropylmagnesium bromide / 1.) THF, RT, 4 h, and reflux, 45 min, 2.) THF, RT, 3 d

2: 98 percent / NaOMe / methanol / 20 h / Ambient temperature

3: 1.) trifluoroacetic acid / 1.) CH₂Cl₂, RT, 35 min, 2.) toluene, reflux, 7 min

4: 70 percent / p-toluenesulfonic acid monohydrate / benzene / Heating

5: 1.) AlH₃, MeOH, 2.) NaBH₄ / 1.) THF, 0 deg C, 12 min, 2.) EtOH, 0 deg C, 18 h

6: 92 percent / aq. H₂SO₄ / tetrahydrofuran / 20 h / Ambient temperature

With aluminium hydride; methanol; sodium tetrahydroborate; sulfuric acid; isopropylmagnesium bromide; toluene-4-sulfonic acid; trifluoroacetic acid; sodium methylate; In tetrahydrofuran; methanol; benzene;
DOI:10.1021/jo00349a006