(1S,2S)-2-[(tert-butyloxycarbonyl)amino]-1-methyl-2-phenylethyl benzoate

Base Information

Chemical Name:(1S,2S)-2-[(tert-butyloxycarbonyl)amino]-1-methyl-2-phenylethyl benzoate
CAS No.:526217-50-5
Molecular Formula:C₂₁H₂₅NO₄
Molecular Weight:355.434
Hs Code.:

Synonyms:(1S,2S)-2-[(tert-butyloxycarbonyl)amino]-1-methyl-2-phenylethyl benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2S)-2-[(tert-butyloxycarbonyl)amino]-1-methyl-2-phenylethyl benzoate

Chemical Property:

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Technology Process of (1S,2S)-2-[(tert-butyloxycarbonyl)amino]-1-methyl-2-phenylethyl benzoate

There total 3 articles about (1S,2S)-2-[(tert-butyloxycarbonyl)amino]-1-methyl-2-phenylethyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 65-85-0,8013-63-6
benzoic acid

: 526217-24-3
tert-butyl (1S,2R)-2-hydroxy-1-phenylpropylcarbamate

: 526217-50-5
(1S,2S)-2-[(tert-butyloxycarbonyl)amino]-1-methyl-2-phenylethyl benzoate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 0 ℃; for 2h;
DOI:10.1016/S0968-0896(02)00380-2

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 526217-50-5
(1S,2S)-2-[(tert-butyloxycarbonyl)amino]-1-methyl-2-phenylethyl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / 2 M NaOH / dioxane / 3 h / 0 °C

2: 83 percent / PPh₃; DEAD / tetrahydrofuran; toluene / 2 h / 0 °C

With sodium hydroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; toluene; 2: Mitsunobu reaction;
DOI:10.1016/S0968-0896(02)00380-2

Reference yield:

: 133735-64-5
(1S,2R)-(+)-1-amino-1-phenyl-2-propanol hydrochloride

: 526217-50-5
(1S,2S)-2-[(tert-butyloxycarbonyl)amino]-1-methyl-2-phenylethyl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / 2 M NaOH / dioxane / 3 h / 0 °C

2: 83 percent / PPh₃; DEAD / tetrahydrofuran; toluene / 2 h / 0 °C

With sodium hydroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; toluene; 2: Mitsunobu reaction;
DOI:10.1016/S0968-0896(02)00380-2