526217-24-3

Basic information

• Product Name: tert-butyl (1S,2R)-2-hydroxy-1-phenylpropylcarbamate
• Synonyms: tert-butyl (1S,2R)-2-hydroxy-1-phenylpropylcarbamate
• CAS NO: 526217-24-3
• Molecular Weight: 251.326
• Mol File: 526217-24-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: tert-butyl (1S,2R)-2-hydroxy-1-phenylpropylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (1S,2R)-2-hydroxy-1-phenylpropylcarbamate(526217-24-3)
• EPA Substance Registry System: tert-butyl (1S,2R)-2-hydroxy-1-phenylpropylcarbamate(526217-24-3)

Safety Data

• Hazardous Substances Data: 526217-24-3(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 133735-64-5 (1S,2R)-(+)-1-amino-1-phenyl-2-propanol hydrochloride 
• 14212-54-5 (+)-(R,R)-β-methylstyrene oxide 
• 88082-67-1 (1S,2R)-1-amino-1-phenylpropan-2-ol 
• 2935-35-5 (S)-2-phenylglycine 
• 2900-27-8 (2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid 
• 216769-51-6 tert-butyl (S)-{2-[methoxy(methyl)amino]-2-oxo-1-phenylethyl}carbamate 
• 1395897-82-1 (S)-tert-butyl (2-oxo-1-phenylpropyl)carbamate 
• 155396-71-7 tert-butyl N-(phenyl(phenylsulfonyl)methyl)carbamate 
• 172613-65-9 N-(2-oxo-1-phenyl-1-propyl)-carbamic acid tert-butyl ester 

Downstream Products

• 159406-31-2 (4S,5R)-5-Methyl-4-phenyl-2-oxazolidinone 
• 526217-56-1 (1S,2S)-1-methyl-2-phenyl-2-(octanoylamino)ethyl bis(2,2,2-trichloroethyl) phosphate 
• 526217-55-0 {(1S,2S)-2-[Bis-(2,2,2-trichloro-ethoxy)-phosphoryloxy]-1-phenyl-propyl}-carbamic acid tert-butyl ester 
• 526217-25-4 tert-butyl (1S,2S)-2-hydroxy-1-phenylpropylcarbamate 
• 526217-50-5 (1S,2S)-2-[(tert-butyloxycarbonyl)amino]-1-methyl-2-phenylethyl benzoate 

Relevant articles and documents

Asymmetric Transfer Hydrogenation: Dynamic Kinetic Resolution of α-Amino Ketones

A series of α-amino ketones were reduced using asymmetric transfer hydrogenation (ATH) through a dynamic kinetic resolution (DKR). The protecting group was matched to the reducing agent, and following optimization, a series of substrates were investigated, giving products in high diastereoselectivity, over 99% ee in several cases and full conversion. The methodology was applied to the enantioselective synthesis of an MDM2-p53 inhibitor precursor.

Examining the origin of selectivity in the reaction of racemic alcohols with chiral N-phosphoryl oxazolidinones

A range of known and novel N-phosphoryl oxazolidinones and imidazolidinones were prepared and screened in the kinetic resolution of a range of racemic magnesium chloroalkoxides. Models are proposed to account for the enantioselectivity achieved based on a combination of chiral relay effects, generation of transient stereochemistry and the structure of the intermediate magnesium alkoxide.

Highly potent inhibitors of TNF-α production. Part II: Metabolic stabilization of a newly found chemical lead and conformational analysis of an active diastereoisomer

Design and synthesis of metabolically stabilized inhibitors of TNF-α production, which could be new drug candidates, are reported. Conformational analysis of an active diastereoisomer was performed based on biological evaluations of the conformationally f