526217-24-3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 133735-64-5 (1S,2R)-(+)-1-amino-1-phenyl-2-propanol hydrochloride 
• 2935-35-5 (S)-2-phenylglycine 
• 2900-27-8 (2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid 
• 216769-51-6 tert-butyl (S)-{2-[methoxy(methyl)amino]-2-oxo-1-phenylethyl}carbamate 
• 1395897-82-1 (S)-tert-butyl (2-oxo-1-phenylpropyl)carbamate 
• 172613-65-9 N-(2-oxo-1-phenyl-1-propyl)-carbamic acid tert-butyl ester 
• 155396-71-7 tert-butyl N-(phenyl(phenylsulfonyl)methyl)carbamate 
• 88082-67-1 (1S,2R)-1-amino-1-phenylpropan-2-ol 
• 14212-54-5 (+)-(R,R)-β-methylstyrene oxide 

Downstream Products

• 526217-50-5 (1S,2S)-2-[(tert-butyloxycarbonyl)amino]-1-methyl-2-phenylethyl benzoate 
• 159406-31-2 (4S,5R)-5-Methyl-4-phenyl-2-oxazolidinone 
• 526217-56-1 (1S,2S)-1-methyl-2-phenyl-2-(octanoylamino)ethyl bis(2,2,2-trichloroethyl) phosphate 
• 526217-55-0 {(1S,2S)-2-[Bis-(2,2,2-trichloro-ethoxy)-phosphoryloxy]-1-phenyl-propyl}-carbamic acid tert-butyl ester 
• 526217-25-4 tert-butyl (1S,2S)-2-hydroxy-1-phenylpropylcarbamate 

Relevant academic research and scientific papers

Asymmetric Transfer Hydrogenation: Dynamic Kinetic Resolution of α-Amino Ketones

A series of α-amino ketones were reduced using asymmetric transfer hydrogenation (ATH) through a dynamic kinetic resolution (DKR). The protecting group was matched to the reducing agent, and following optimization, a series of substrates were investigated, giving products in high diastereoselectivity, over 99% ee in several cases and full conversion. The methodology was applied to the enantioselective synthesis of an MDM2-p53 inhibitor precursor.

Diastereo- and Enantioselective Synthesis of β-Aminoboronate Esters by Copper(I)-Catalyzed 1,2-Addition of 1,1-Bis[(pinacolato)boryl]alkanes to Imines

Reported herein is an efficient copper(I)-catalytic system for the diastereo- and enantioselective 1,2-addition of 1,1-bis[(pinacolato)boryl]alkanes to protected imines to afford synthetically valuable enantioenriched β-aminoboron compounds bearing contiguous stereogenic centers. The reaction exhibits a broad scope with respect to protected imines and 1,1-bis[(pinacolato)boryl]alkanes, thus providing β-aminoboronate esters with excellent diastereo- and enantioselectivity. The synthetic utility of the obtained β-aminoboronate ester was also demonstrated.

Examining the origin of selectivity in the reaction of racemic alcohols with chiral N-phosphoryl oxazolidinones

A range of known and novel N-phosphoryl oxazolidinones and imidazolidinones were prepared and screened in the kinetic resolution of a range of racemic magnesium chloroalkoxides. Models are proposed to account for the enantioselectivity achieved based on a combination of chiral relay effects, generation of transient stereochemistry and the structure of the intermediate magnesium alkoxide.

METHOD FOR THE PREPARATION OF AMINOPHOSPHINE LIGANDS AND THEIR USE IN METAL CATALYSTS

The present application is directed to i) a two-step method for synthesizing phosphme-ammophosphme (P,N,P) ligands, ii) the use of such ligands in the preparation of metal complexes as hydrogenation catalysts, and iii) ammophosphme (P,N) and phosphme-ammo

Highly potent inhibitors of TNF-α production. Part II: Metabolic stabilization of a newly found chemical lead and conformational analysis of an active diastereoisomer

Design and synthesis of metabolically stabilized inhibitors of TNF-α production, which could be new drug candidates, are reported. Conformational analysis of an active diastereoisomer was performed based on biological evaluations of the conformationally f