Technology Process of p-cyanophenyldichlorophosphine
There total 4 articles about p-cyanophenyldichlorophosphine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-cyanophenyldiazonium tetrafluoroborate;
With
copper(I) bromide; phosphorus trichloride;
In
ethyl acetate;
at 45 ℃;
for 1h;
With
magnesium;
In
ethyl acetate;
at 30 - 40 ℃;
for 3h;
DOI:10.1016/S0968-0896(01)00259-0
- Guidance literature:
-
With
phosphorus trichloride;
In
tetrahydrofuran;
at -100 - 20 ℃;
for 16h;
Inert atmosphere;
Schlenk technique;
DOI:10.1021/acs.joc.1c01560
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -100 °C / Inert atmosphere; Schlenk technique
1.2: 0.5 h / -100 °C / Inert atmosphere; Schlenk technique
2.1: phosphorus trichloride / tetrahydrofuran / 16 h / -100 - 20 °C / Inert atmosphere; Schlenk technique
With
n-butyllithium; phosphorus trichloride;
In
tetrahydrofuran; hexane;
DOI:10.1021/acs.joc.1c01560
