((1S,2R)-1-Benzyl-3-cyano-2-methoxymethoxy-propyl)-methyl-carbamic acid benzyl ester

Base Information

Chemical Name:((1S,2R)-1-Benzyl-3-cyano-2-methoxymethoxy-propyl)-methyl-carbamic acid benzyl ester
CAS No.:260562-78-5
Molecular Formula:C₂₂H₂₆N₂O₄
Molecular Weight:382.459
Hs Code.:

Synonyms:((1S,2R)-1-Benzyl-3-cyano-2-methoxymethoxy-propyl)-methyl-carbamic acid benzyl ester

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Chemical Property of ((1S,2R)-1-Benzyl-3-cyano-2-methoxymethoxy-propyl)-methyl-carbamic acid benzyl ester

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Technology Process of ((1S,2R)-1-Benzyl-3-cyano-2-methoxymethoxy-propyl)-methyl-carbamic acid benzyl ester

There total 7 articles about ((1S,2R)-1-Benzyl-3-cyano-2-methoxymethoxy-propyl)-methyl-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 13057-17-5
bromethyl methyl ether

: 260562-77-4
((1S,2R)-1-Benzyl-3-cyano-2-hydroxy-propyl)-methyl-carbamic acid benzyl ester

: 260562-78-5
((1S,2R)-1-Benzyl-3-cyano-2-methoxymethoxy-propyl)-methyl-carbamic acid benzyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; at 0 - 20 ℃;
DOI:10.1016/S0040-4039(99)01953-X

Reference yield:

: 78571-81-0,81096-89-1,85531-71-1,99883-80-4,128575-26-8,116949-62-3
(R,R)-3-(phenylmethyl)oxiranemethanol

: 260562-78-5
((1S,2R)-1-Benzyl-3-cyano-2-methoxymethoxy-propyl)-methyl-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: Ti(iPrO)2(N₃)2 / benzene / 75 °C

2: 66 percent / H₂ / 10 percent Pd/C / methanol / 760 Torr

3: 74 percent / NaHCO₃ / H₂O / 50 °C

4: 69 percent / PPh₃; DEAD / CHCl₃ / Heating

5: 69 percent / NaH / tetrahydrofuran / 0 °C

6: 54 percent / NEt₃ / tetrahydrofuran / Heating

7: 67 percent / iPr₂NEt / 0 - 20 °C

With diisopropoxytitanium diazide; hydrogen; sodium hydride; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; 10% palladium on active carbon; In tetrahydrofuran; methanol; chloroform; water; benzene; 1: Ring cleavage / 2: Catalytic hydrogenation / 3: Acylation / 4: Mitsunobu cyclization / 5: Methylation / 6: Ring cleavage / 7: Etherification;
DOI:10.1016/S0040-4039(99)01953-X

Reference yield:

: 116949-67-8
(2S,3S)-2-azido-1-phenyl-butane-3,4-diol

: 260562-78-5
((1S,2R)-1-Benzyl-3-cyano-2-methoxymethoxy-propyl)-methyl-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 66 percent / H₂ / 10 percent Pd/C / methanol / 760 Torr

2: 74 percent / NaHCO₃ / H₂O / 50 °C

3: 69 percent / PPh₃; DEAD / CHCl₃ / Heating

4: 69 percent / NaH / tetrahydrofuran / 0 °C

5: 54 percent / NEt₃ / tetrahydrofuran / Heating

6: 67 percent / iPr₂NEt / 0 - 20 °C

With hydrogen; sodium hydride; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; 10% palladium on active carbon; In tetrahydrofuran; methanol; chloroform; water; 1: Catalytic hydrogenation / 2: Acylation / 3: Mitsunobu cyclization / 4: Methylation / 5: Ring cleavage / 6: Etherification;
DOI:10.1016/S0040-4039(99)01953-X