tert-butyl 3-(3-(4-fluorophenylsulfinyl)isoquinolin-1-ylamino)-5-methyl-1H-pyrazole-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-(3-(4-fluorophenylsulfinyl)isoquinolin-1-ylamino)-5-methyl-1H-pyrazole-1-carboxylate
CAS No.:1362689-56-2
Molecular Formula:C₂₄H₂₃FN₄O₃S
Molecular Weight:466.536
Hs Code.:

Synonyms:tert-butyl 3-(3-(4-fluorophenylsulfinyl)isoquinolin-1-ylamino)-5-methyl-1H-pyrazole-1-carboxylate

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Chemical Property of tert-butyl 3-(3-(4-fluorophenylsulfinyl)isoquinolin-1-ylamino)-5-methyl-1H-pyrazole-1-carboxylate

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Technology Process of tert-butyl 3-(3-(4-fluorophenylsulfinyl)isoquinolin-1-ylamino)-5-methyl-1H-pyrazole-1-carboxylate

There total 6 articles about tert-butyl 3-(3-(4-fluorophenylsulfinyl)isoquinolin-1-ylamino)-5-methyl-1H-pyrazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1362689-55-1
1-bromo-3-(4-fluorophenylsulfinyl)isoquinoline

: 578008-32-9
tert-butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate

: 1362689-56-2
tert-butyl 3-(3-(4-fluorophenylsulfinyl)isoquinolin-1-ylamino)-5-methyl-1H-pyrazole-1-carboxylate

Guidance literature:: With sodium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene; In water; toluene; at 80 ℃; for 15h; Inert atmosphere;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1362689-56-2
tert-butyl 3-(3-(4-fluorophenylsulfinyl)isoquinolin-1-ylamino)-5-methyl-1H-pyrazole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2.5 h / 0 - 20 °C

2: sodium carbonate / 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene; water / 3.5 h / 100 °C / Sealed tube; Microwave irradiation

With sodium hydride; sodium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene; In water; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 7742-73-6
1,3-dichloroisoquinoline

: 1362689-56-2
tert-butyl 3-(3-(4-fluorophenylsulfinyl)isoquinolin-1-ylamino)-5-methyl-1H-pyrazole-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium / acetonitrile / 1.5 h / 65 °C

2: CsCO₃ / ISOPROPYLAMIDE / 0.33 h / 100 °C / Sealed tube; Microwave irradiation

3: phosphorus(V) oxybromide / toluene / 1 h / 120 °C

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.25 h / -10 - 0 °C

5: sodium carbonate / 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene; water / 3.5 h / 100 °C / Sealed tube; Microwave irradiation

With CsCO₃; sodium; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; phosphorus(V) oxybromide; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene; In dichloromethane; ISOPROPYLAMIDE; water; toluene; acetonitrile;