[3-benzo[1,3]dioxol-4-yl-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-pyridin-3-yl-amine

Base Information

Chemical Name:[3-benzo[1,3]dioxol-4-yl-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-pyridin-3-yl-amine
CAS No.:915412-16-7
Molecular Formula:C₃₄H₃₂N₂O₃Si
Molecular Weight:544.725
Hs Code.:

Synonyms:[3-benzo[1,3]dioxol-4-yl-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-pyridin-3-yl-amine

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Chemical Property of [3-benzo[1,3]dioxol-4-yl-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-pyridin-3-yl-amine

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Technology Process of [3-benzo[1,3]dioxol-4-yl-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-pyridin-3-yl-amine

There total 7 articles about [3-benzo[1,3]dioxol-4-yl-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-pyridin-3-yl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6698-13-1
4-bromo-benzo[1,3]dioxole

: 915412-15-6
[3-(tert-butyl-diphenyl-silanyloxy)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-pyridin-3-yl-amine

: 915412-16-7
[3-benzo[1,3]dioxol-4-yl-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-pyridin-3-yl-amine

Guidance literature:: With potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex; In 1,4-dioxane; water;

Reference yield:

: 915412-13-4
3-Bromo-5-(pyridin-3-ylamino)-phenol

: 915412-16-7
[3-benzo[1,3]dioxol-4-yl-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-pyridin-3-yl-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 20 h / 0 - 20 °C

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 16 h / 80 °C

3.1: potassium phosphate / chloro(di-2-norbornylphosphino)(2'dimethylamino-1,1'-biphenyl-2-yl)palladium(II) / 1,4-dioxane; water / 100 °C

With potassium phosphate; potassium acetate; sodium hydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; chloro(di-2-norbornylphosphino)(2'dimethylamino-1,1'-biphenyl-2-yl)palladium(II); In 1,4-dioxane; water; N,N-dimethyl-formamide; 3.1: Suzuki Coupling;

Reference yield:

: 915410-93-4
1,3-dibromo-5-((4-methoxybenzyl)oxy)-benzene

: 915412-16-7
[3-benzo[1,3]dioxol-4-yl-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-pyridin-3-yl-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium t-butanolate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 40.17 h / 90 °C

2.1: methyl-phenyl-thioether; trifluoroacetic acid / 3.67 h / 20 - 25 °C

2.2: pH 7

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

3.2: 20 h / 0 - 20 °C

4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 16 h / 80 °C

5.1: potassium phosphate / chloro(di-2-norbornylphosphino)(2'dimethylamino-1,1'-biphenyl-2-yl)palladium(II) / 1,4-dioxane; water / 100 °C

With potassium phosphate; methyl-phenyl-thioether; potassium acetate; sodium hydride; trifluoroacetic acid; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; chloro(di-2-norbornylphosphino)(2'dimethylamino-1,1'-biphenyl-2-yl)palladium(II); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene; 1.1: Buchwald reaction / 5.1: Suzuki Coupling;