6698-13-1Relevant academic research and scientific papers
FUSED RING PYRIMIDINE COMPOUND, INTERMEDIATE, AND PREPARATION METHOD, COMPOSITION AND USE THEREOF
-
Paragraph 0386-0388, (2018/08/12)
Disclosed area fused ring pyrimidine compound, and an intermediate, a preparation method, a composition and a use thereof. The fused ring pyrimidine compound is a compound as shown in formula I, a tautomer, an enantiomer, a diastereoisomer, a pharmaceutically acceptable salt, a metabolite, a metabolic precursor or a prodrug thereof, wherein the above-mentioned compound is used for the preparation of a medicine for preventing, remitting or treating one or more of immune system diseases, autoimmune diseases, cell proliferative diseases, allergic disorders and cardiovascular diseases, and the compound has a strong inhibitory effect on the Janues kinase, FGFR kinase, FLT3 kinase and Src family kinase.
Synthesis of ACAT inhibitors through substitution using allylic picolinate and copper reagent
Kobayashi, Yuichi,Lalitnorasate, Paveena,Kaneko, Yuki,Kiyotsuka, Yohei,Endo, Yoshiki
scheme or table, p. 6018 - 6021 (2010/11/21)
Amide of an octanoic acid possessing an aryl group at C3 position is a highly potent ACAT inhibitor. In this paper, we describe a synthetic access to this class of compounds as optically active forms. The key reaction is substitution of the allylic picoli
Synthesis of 5,6-methylenedioxy-1-tetralone. An aryl Grignard approach from guaiacol
Klix, Russell C.,Cain, Michael H.,Bhatia, Ashok V.
, p. 6413 - 6414 (2007/10/02)
A convenient synthesis of 5,6-methylenedioxy-1-tetralone (1) is described. The main features of this synthesis are the formation of 6 via a Grignard reaction using succinic anhydride followed by selective reduction and Friedel-Crafts cyclization to generate the desired tetralone 1.
Phenyl-substituted sulfonamides
-
, (2008/06/13)
Novel N-[pyrimidin-2-yl]- and [triazin-2-yl]-aminocarbonyl]-1,3-benzodioxolesulfonamides and 1,4-benzodioxansulfonamides are useful as plant growth regulants and in particular as herbicides.
Substituted sulfonamides 1,3-benzodioxole
-
, (2008/06/13)
Novel N-[pyrimidin-2-yl]- and [triazin-2-yl]aminocarbonyl-1,3-benzodioxolesulfonamides and 1,4-benzodioxansulfonamides are useful as plant growth regulants and in particular as herbicides.
