N-<4-(7-methanesulfonamido-10H-indolo<3,2-b>quinolin-11-yl)amino-3-methoxyphenyl>methanesulfonamide

Base Information

Chemical Name:N-<4-(7-methanesulfonamido-10H-indolo<3,2-b>quinolin-11-yl)amino-3-methoxyphenyl>methanesulfonamide
CAS No.:144398-18-5
Molecular Formula:C₂₄H₂₃N₅O₅S₂
Molecular Weight:525.609
Hs Code.:

Synonyms:N-<4-(7-methanesulfonamido-10H-indolo<3,2-b>quinolin-11-yl)amino-3-methoxyphenyl>methanesulfonamide

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Chemical Property of N-<4-(7-methanesulfonamido-10H-indolo<3,2-b>quinolin-11-yl)amino-3-methoxyphenyl>methanesulfonamide

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Technology Process of N-<4-(7-methanesulfonamido-10H-indolo<3,2-b>quinolin-11-yl)amino-3-methoxyphenyl>methanesulfonamide

There total 4 articles about N-<4-(7-methanesulfonamido-10H-indolo<3,2-b>quinolin-11-yl)amino-3-methoxyphenyl>methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 131058-13-4
N-<4-(7-amino-10H-indolo<3,2-b>quinolin-11-yl)amino-3-methoxyphenyl>methanesulfonamide

: 124-63-0
methanesulfonyl chloride

: 144398-18-5
N-<4-(7-methanesulfonamido-10H-indolo<3,2-b>quinolin-11-yl)amino-3-methoxyphenyl>methanesulfonamide

Guidance literature:: With pyridine; at 70 ℃; for 6h;
DOI:10.1248/cpb.40.1481

Reference yield:

: 80271-19-8
11-chloro-10H-indolo-[3,2-b]quinoline

: 144398-18-5
N-<4-(7-methanesulfonamido-10H-indolo<3,2-b>quinolin-11-yl)amino-3-methoxyphenyl>methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / conc. nitric acid / acetic acid / 10 h / Ambient temperature

2: 67 percent / 2-ethoxy-ethanol / 8 h / Heating

3: 72 percent / H₂ / 10percent Pd/C / acetic acid / 48 h / 760 Torr

4: 90 percent / pyridine / 6 h / 70 °C

With pyridine; hydrogen; nitric acid; palladium on activated charcoal; In 2-ethoxy-ethanol; acetic acid;
DOI:10.1248/cpb.40.1481

Reference yield:

: 131058-48-5
11-chloro-7-nitro-10H-indolo<3,2-b>quinoline

: 144398-18-5
N-<4-(7-methanesulfonamido-10H-indolo<3,2-b>quinolin-11-yl)amino-3-methoxyphenyl>methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / 2-ethoxy-ethanol / 8 h / Heating

2: 72 percent / H₂ / 10percent Pd/C / acetic acid / 48 h / 760 Torr

3: 90 percent / pyridine / 6 h / 70 °C

With pyridine; hydrogen; palladium on activated charcoal; In 2-ethoxy-ethanol; acetic acid;
DOI:10.1248/cpb.40.1481