methyl 4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)-2-methoxybenzoate

Base Information

Chemical Name:methyl 4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)-2-methoxybenzoate
CAS No.:1464153-83-0
Molecular Formula:C₂₂H₁₆N₄O₃
Molecular Weight:384.394
Hs Code.:

Synonyms:methyl 4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)-2-methoxybenzoate

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Chemical Property of methyl 4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)-2-methoxybenzoate

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Technology Process of methyl 4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)-2-methoxybenzoate

There total 3 articles about methyl 4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 603122-41-4
(3-methoxy-4-(methoxycarbonyl)phenyl)boronic acid

: 1464153-49-8
4-(6-bromoimidazo[1,2-a]pyrazin-3-vl)benzonitrile

: 1464153-83-0
methyl 4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)-2-methoxybenzoate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; at 90 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1245644-42-1
6-bromo-3-iodo-imidazo[1,2-a]pyrazine

: 1464153-83-0
methyl 4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / water; N,N-dimethyl-formamide / 1 h / 90 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 3 h / 90 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 126747-14-6
4-cyanophenylboronic acid

: 1464153-83-0
methyl 4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / water; N,N-dimethyl-formamide / 1 h / 90 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 3 h / 90 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;