tert-butyl 4-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)-2-methoxybenzoyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)-2-methoxybenzoyl)piperazine-1-carboxylate
CAS No.:1464153-89-6
Molecular Formula:C₃₀H₃₀N₆O₄
Molecular Weight:538.606
Hs Code.:

Synonyms:tert-butyl 4-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)-2-methoxybenzoyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)-2-methoxybenzoyl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)-2-methoxybenzoyl)piperazine-1-carboxylate

There total 5 articles about tert-butyl 4-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)-2-methoxybenzoyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1464153-85-2
4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)-2-methoxybenzoic acid

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1464153-89-6
tert-butyl 4-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)-2-methoxybenzoyl)piperazine-1-carboxylate

Guidance literature:: With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 10h;

Reference yield:

: 1464153-83-0
methyl 4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)-2-methoxybenzoate

: 1464153-89-6
tert-butyl 4-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)-2-methoxybenzoyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide; water / methanol; tetrahydrofuran / 5 h / 20 °C

2: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 10 h / 20 °C

With 4-methyl-morpholine; water; HATU; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1245644-42-1
6-bromo-3-iodo-imidazo[1,2-a]pyrazine

: 1464153-89-6
tert-butyl 4-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)-2-methoxybenzoyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / water; N,N-dimethyl-formamide / 1 h / 90 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 3 h / 90 °C / Inert atmosphere

3: lithium hydroxide; water / methanol; tetrahydrofuran / 5 h / 20 °C

4: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 10 h / 20 °C

With 4-methyl-morpholine; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; HATU; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;