(R)-methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno-[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate

Base Information

Chemical Name:(R)-methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno-[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate
CAS No.:1360923-54-1
Molecular Formula:C₁₆H₁₆ClNO₃S
Molecular Weight:337.827
Hs Code.:

Synonyms:(R)-methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno-[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate

Suppliers and Price of (R)-methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno-[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of (R)-methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno-[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate

Chemical Property:

Purity/Quality:: HPLC ≥ 98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of (R)-methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno-[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate

There total 2 articles about (R)-methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno-[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: C₁₅H₁₂ClNO₇S

: 1360923-54-1,109904-27-0
(R)-methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno-[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate

Guidance literature:: With potassium hydrogencarbonate; In acetonitrile; at 20 ℃; for 26h; Inert atmosphere;
DOI:10.1021/jm300038c

Reference yield:

: 32345-60-1
methyl (S)-2-hydroxy-2-(2-chlorophenyl)acetate

: 1360923-54-1,109904-27-0
(R)-methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno-[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane / 4 h / 0 °C

2: potassium hydrogencarbonate / acetonitrile / 26 h / 20 °C / Inert atmosphere

With dmap; potassium hydrogencarbonate; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jm300038c

Reference yield:

: 1360923-54-1,109904-27-0
(R)-methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno-[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate

: 767612-34-0
C₁₆H₁₈ClNO₄S

Guidance literature:: With potassium dihydrogenphosphate; magnesium(II) chloride hexahydrate; D-glucose; water; G₆PDH dehydrogenase; P₄₅₀ synthase; NADPH; sodium hydroxide; In dimethyl sulfoxide; at 30 ℃; for 0.5h; pH=7.4; Enzymatic reaction;