Validamycin A

Base Information

Chemical Name:Validamycin A
CAS No.:37248-47-8
Molecular Formula:C20H35NO13
Molecular Weight:497.497
Hs Code.:
European Community (EC) Number:609-372-4
UNII:313E9620QS
DSSTox Substance ID:DTXSID4058073
Nikkaji Number:J108.001F
Wikipedia:Validamycin
Metabolomics Workbench ID:69803
ChEMBL ID:CHEMBL1923413
Mol file:37248-47-8.mol

Synonyms:jinggangmycin;Validacin;validamycin A

Suppliers and Price of Validamycin A

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Validamycin A
250mg
$ 350.00

Crysdot
Validamycin 97%
250mg
$ 180.00

ChemScene
ValidamycinA
100mg
$ 50.00

Cayman Chemical
Validamycin A ≥60%
25 mg
$ 39.00

Cayman Chemical
Validamycin A ≥60%
100 mg
$ 140.00

Cayman Chemical
Validamycin A ≥60%
1g
$ 134.00

Cayman Chemical
Validamycin A ≥60%
500mg
$ 89.00

Cayman Chemical
Validamycin A ≥60%
50 mg
$ 74.00

BLDpharm
ValidamycinA 60+%
250mg
$ 60.00

American Custom Chemicals Corporation
VALIDAMYCIN 95.00%
500MG
$ 478.00

Total 120 raw suppliers

Chemical Property of Validamycin A

Chemical Property:

Appearance/Colour:white powder
Vapor Pressure:0mmHg at 25°C
Melting Point:130-135 °C
Refractive Index:1.689
Boiling Point:813.7 °C at 760 mmHg
PKA:6.0(at 25℃)
Flash Point:445.9 °C
PSA：253.02000
Density:1.69 g/cm³
LogP:-6.36180
Storage Temp.:0-6°C
Water Solubility.:Readily soluble
XLogP3:-6.3
Hydrogen Bond Donor Count:12
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:7
Exact Mass:497.21084017
Heavy Atom Count:34
Complexity:697

Purity/Quality:

99% ^*data from raw suppliers

Validamycin A ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Chemical Classes:Pesticides -> Fungicides
Canonical SMILES:C1C(C(C(C(C1NC2C=C(C(C(C2O)O)O)CO)O)O)OC3C(C(C(C(O3)CO)O)O)O)CO
Isomeric SMILES:C1[C@@H]([C@H]([C@@H]([C@H]([C@H]1N[C@H]2C=C([C@H]([C@@H]([C@H]2O)O)O)CO)O)O)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)CO
Description Validamycin A is produced by the fermentation of Streptomyces hygroscopicus var. limoneus nov. var (30). Structure revised (31). Colorless, odorless, hygroscopic powder. V.p. Negligible at room temperature. Solubility: Readily soluble in water, soluble in methanol, dimethylformamide and dimethyl sulfoxide. Slightly soluble in ethanol and acetone. Sparingly soluble in diethyl ether and ethyl acetate. pKa 6.0 Stability [α]24D + 110? (water).
Uses Validamycin A (>70%) Hydrochloride Salt is a metabolite of Validamycin A (>70%) (V943430) which is an antibiotic fungicide that inhibits trehalase activity in plants, insects, and fungi. Validamycin A is the major analogue of a family of cyclitol disaccharides isolated from Streptomyces hygroscopicus var. limoneus by researchers at Takeda in 1970. Although commonly regarded as an aminoglycoside, validamycin shares little in common with conventional aminoglycosides such as streptomycin and gentamicin. Validamycin A is a potent antifungal agent and is used to control fungi in crop production. Validamycin A acts as a potent inhibitor of trehalase, an important enzyme in carbohydrate storage and ultilisation in fungi. Validamycin A is used for the control of Rhizoctonia diseases in rice (sheath blight), potatoes, vegetables, strawberries, tobacco and other crops.

Technology Process of Validamycin A

There total 20 articles about Validamycin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: