D-Glucose

Base Information

• Chemical Name: D-Glucose
• CAS No.: 2280-44-6
• Molecular Formula: C6H12 O6
• Molecular Weight: 180.158
• European Community (EC) Number: 218-914-5,607-980-4,807-615-0,807-616-6
• DSSTox Substance ID: DTXSID501015215,DTXSID901015217
• Nikkaji Number: J213.160I
• Wikipedia: Glucose
• Wikidata: Q23905964
• NCI Thesaurus Code: C2831
• RXCUI: 4850
• Metabolomics Workbench ID: 37084
• ChEMBL ID: CHEMBL1222250
• Mol file: 2280-44-6.mol

Synonyms:Anhydrous Dextrose;D Glucose;D-Glucose;Dextrose;Dextrose, Anhydrous;Glucose;Glucose Monohydrate;Glucose, (alpha-D)-Isomer;Glucose, (beta-D)-Isomer;Glucose, (DL)-Isomer;Glucose, (L)-Isomer;L Glucose;L-Glucose;Monohydrate, Glucose

Chemical Property of D-Glucose

Chemical Property:

• Vapor Pressure: 1.83E-08mmHg at 25°C
• Melting Point: 152-155°C
• Boiling Point: 410.8°C at 760 mmHg
• Flash Point: 202.2°C
• PSA: 110.38000
• Density: 1.732g/cm³
• LogP: -3.22140
• Storage Temp.: Refrigerator
• XLogP3: -2.6
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 1
• Exact Mass: 180.06338810
• Heavy Atom Count: 12
• Complexity: 151

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C(C1C(C(C(C(O1)O)O)O)O)O
• Isomeric SMILES: C([C@@H]1[C@H]([C@@H]([C@H](C(O1)O)O)O)O)O
• Recent ClinicalTrials: Taste Physiology in Obese Volunteers Before and After Bariatric Surgery
• Recent EU Clinical Trials: A Study to Evaluate the EffIcacy and Safety of XyloCore, a Glucose Sparing Experimental Solution, for Peritoneal Dialysis
• Recent NIPH Clinical Trials: A Randomized Controlled Trial of the Efficacy of Blood Glucose and Diet and Physical Activity Monitoring
• Uses: D-Glucose is a simple sugar that is present in plants. A monosaccharide that may exist in open chain or cyclic conformation if in solution. It plays a vital role in photosynthesis and fuels the energ y required for cellular respiration. D-Glucose is used in various metabolic processes including enzymic synthesis of cyclohexyl-α and β-D-glucosides. Can also be used as a diagnostic tool in detection of type 2 diabetes mellitus and potentially Huntington's disease through analysis of blood-glucose in type 1 diabetes mellitus. Used in enzymic synthesis of cyclohexyl-α and β-D-glucosides

Technology Process of D-Glucose

There total 1242 articles about D-Glucose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

N-hydroxyethylacrylamide (7646-67-5,28156-60-7) + 4-nitrophenyl-β-D-glucoside (2492-87-7) → D-Glucose (2280-44-6) + 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + N-acryloyl-2-aminoethyl β-D-glucopyranoside (156884-56-9)

Guidance literature:

With β-glucosidase; In water; at 50 ℃; for 1h; Ionic liquid; Enzymatic reaction;

DOI:10.1039/c7gc03023a

Reference yield:

methanol (67-56-1) + p-nitrophenyl 65-O-benzyl-α-maltopentaoside (115850-12-9) → D-Glucose (2280-44-6) + 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + methyl 6-O-benzyl-α-D-glucopyranoside (20839-38-7,23392-30-5,23392-33-8,63864-93-7,65309-96-8,65309-99-1,67393-10-6,82264-32-2,23392-32-7)

Guidance literature:

With hydrogenchloride; at 90 ℃; for 2h; Product distribution;

DOI:10.1016/0008-6215(88)84062-X

Reference yield:

4-nitrophenyl-β-D-glucoside (2492-87-7) → D-Glucose (2280-44-6) + 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0)

Guidance literature:

With β-D-glucosidase; 4-methoxy-phenol; at 30 ℃; Rate constant; hydrolisys at pH=6.7;

DOI:10.1016/S0008-6215(00)81037-X

upstream raw materials:

Daucosterol

astragalin

isoquercetin

Gitoxigenin 3-O-monodigitalosideglucoside, or digitalinum verum

Downstream raw materials:

6-O-Oleoyl-D-glucopyranose

6-O-Dodecanoyl-α-D-glucose

6-O-(N-Carbobenzoxy-α-L-aspartyl)-D-glucose

6-O-(N-Benzyloxycarbonyl-glycyl)-D-glucose

Refernces

Some Amines Derived from 3-Phenyl-1-indanone

10.1021/ja01646a074

The study explores the isomerization of D-glucose to D-mannose using a resin catalyst in carbon dioxide-free water under nitrogen, yielding D-mannose phenylhydrazone. It also investigates the synthesis of amines derived from 3-phenyl-1-indanone through the Mannich reaction with various amines (dimethylamine, diethylamine, piperidine, and morpholine) and formaldehyde, resulting in low yields and unstable products. Further reductions and hydrogenations of these products led to the formation of indene derivatives and aminoalcohols, but no significant pharmacologic activity was observed. Additionally, the study examines the Mannich reaction of p-nitroacetophenone with different amines and formaldehyde, yielding p-(di)-alkylamino-p-nitropropiophenones, which were further reduced to aminoketones and reacted with phenylhydrazine to form pyrazolines.

Highly selective recognition of monosaccharide based on two-component system in aqueous solution

10.1016/j.tet.2011.03.025

The study presents a highly selective and sensitive detection system for D-fructose in aqueous solution, utilizing water-soluble conjugated polymer PP-S-BINOL and tetraboronic acid functionalized benzyl viologen ToBV. PP-S-BINOL serves as the optic signal reporter, with its fluorescence modulated by electron transfer to ToBV, which acts as both a quencher and receptor. The system's selectivity for D-fructose is attributed to the stable pyranose ester form of D-fructose with ToBV and the spatial positioning of boronic acids on ToBV. The system exhibits a high selectivity for D-fructose over other D-monosaccharides, with an 85-fold increase in response ratio compared to D-glucose at 10 mM concentrations. It also shows a linear response to low concentrations of D-fructose (<10.0 mM) at pH 7.4, with an 11-fold increase in fluorescence intensity observed upon adding 100 mM D-fructose. This system offers a promising strategy for developing highly selective monosaccharide sensors.