3-(tert-butyl-dimethyl-silanyloxy)-1-nitro-1-p-tolylsulfanyl-butan-2-ol

Base Information

Chemical Name:3-(tert-butyl-dimethyl-silanyloxy)-1-nitro-1-p-tolylsulfanyl-butan-2-ol
CAS No.:228716-83-4
Molecular Formula:C₁₇H₂₉NO₄SSi
Molecular Weight:371.573
Hs Code.:

3-(<i>tert</i>-butyl-dimethyl-silanyloxy)-1-nitro-1-<i>p</i>-tolylsulfanyl-butan-2-ol

Synonyms:3-(tert-butyl-dimethyl-silanyloxy)-1-nitro-1-p-tolylsulfanyl-butan-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(tert-butyl-dimethyl-silanyloxy)-1-nitro-1-p-tolylsulfanyl-butan-2-ol

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Technology Process of 3-(tert-butyl-dimethyl-silanyloxy)-1-nitro-1-p-tolylsulfanyl-butan-2-ol

There total 1 articles about 3-(tert-butyl-dimethyl-silanyloxy)-1-nitro-1-p-tolylsulfanyl-butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 150640-22-5
<(4-methylphenyl)thio>nitromethane

: 87727-28-4
(S)-2-tert-butyl-dimethyl-silanyloxy propanal

: 228716-83-4
3-(tert-butyl-dimethyl-silanyloxy)-1-nitro-1-p-tolylsulfanyl-butan-2-ol

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; tert-butyl alcohol; 1.) 0 deg C, 15 min, 2.) r.t., 3 h;

Reference yield: 42.0%

: 228716-83-4
3-(tert-butyl-dimethyl-silanyloxy)-1-nitro-1-p-tolylsulfanyl-butan-2-ol

: 160349-77-9
(1Z,3S)-3-tert-butyldimethylsilyloxy-1-(4'-methylphenylthio)-1-nitrobut-1-ene

Guidance literature:: With methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 - 20 ℃; for 3h;

Reference yield:

: 228716-83-4
3-(tert-butyl-dimethyl-silanyloxy)-1-nitro-1-p-tolylsulfanyl-butan-2-ol

: 2-amino-3-(tert-butyl-dimethyl-silanyloxy)-thiobutyric acid S-p-tolyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 42 percent / MsCl, (i-Pr)2NEt / CH₂Cl₂ / 3 h / -78 - 20 °C

2: 73 percent / BF₃*Et₂O / CH₂Cl₂ / 1.) -78 deg C to r.t., 2 h, 2.) r.t., 2 h

3: 65 percent / tert-BuOOH, BuLi / tetrahydrofuran / 0.17 h / -78 °C

4: 83 percent / 2,6-lutidine / CH₂Cl₂ / 2.5 h / -78 °C

5: NH₃, H₂O / CH₂Cl₂ / 7 h / Ambient temperature

With 2,6-dimethylpyridine; tert.-butylhydroperoxide; n-butyllithium; boron trifluoride diethyl etherate; ammonia; water; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;