benzyl 4-{2-[(3-bromopyridin-2-yl){[2-(trimethylsilyl)ethoxy]methyl}amino]-2-oxoethyl}-3,6-dihydropyridine-1(2H)-carboxylate

Base Information

Chemical Name:benzyl 4-{2-[(3-bromopyridin-2-yl){[2-(trimethylsilyl)ethoxy]methyl}amino]-2-oxoethyl}-3,6-dihydropyridine-1(2H)-carboxylate
CAS No.:883985-01-1
Molecular Formula:C₂₆H₃₄BrN₃O₄Si
Molecular Weight:560.563
Hs Code.:

Synonyms:benzyl 4-{2-[(3-bromopyridin-2-yl){[2-(trimethylsilyl)ethoxy]methyl}amino]-2-oxoethyl}-3,6-dihydropyridine-1(2H)-carboxylate

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Chemical Property of benzyl 4-{2-[(3-bromopyridin-2-yl){[2-(trimethylsilyl)ethoxy]methyl}amino]-2-oxoethyl}-3,6-dihydropyridine-1(2H)-carboxylate

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Technology Process of benzyl 4-{2-[(3-bromopyridin-2-yl){[2-(trimethylsilyl)ethoxy]methyl}amino]-2-oxoethyl}-3,6-dihydropyridine-1(2H)-carboxylate

There total 2 articles about benzyl 4-{2-[(3-bromopyridin-2-yl){[2-(trimethylsilyl)ethoxy]methyl}amino]-2-oxoethyl}-3,6-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 883985-00-0
benzyl 4-{2-[(3-bromopyridin-2-yl)amino]-2-oxoethyl}-3,6-dihydropyridine-1(2H)-carboxylate

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 883985-01-1
benzyl 4-{2-[(3-bromopyridin-2-yl){[2-(trimethylsilyl)ethoxy]methyl}amino]-2-oxoethyl}-3,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 ℃;
DOI:10.1016/j.bmcl.2009.09.066

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 883985-01-1
benzyl 4-{2-[(3-bromopyridin-2-yl){[2-(trimethylsilyl)ethoxy]methyl}amino]-2-oxoethyl}-3,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: benzyl 4-{2-[(3-bromopyridin-2-yl)amino]-2-oxoethyl}-3,6-dihydropyridine-1(2H)-carboxylate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

(2-trimethylethylsilylethoxy)methyl chloride; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 75.0%

: 883985-01-1
benzyl 4-{2-[(3-bromopyridin-2-yl){[2-(trimethylsilyl)ethoxy]methyl}amino]-2-oxoethyl}-3,6-dihydropyridine-1(2H)-carboxylate

: 885032-12-2
benzyl 2-oxo-1-{[2-(trimethylsilyl)ethoxy]methyl}-2,2',3,3'-tetrahydro-1H,1'H-spiro[1,8-naphthyridine-4,4'-pyridine]-1'-carboxylate

Guidance literature:: With bis(tri-t-butylphosphine)palladium⁽⁰⁾; N-Methyldicyclohexylamine; In 1,4-dioxane; at 50 ℃;
DOI:10.1016/j.bmcl.2009.09.066