benzyl 2-oxo-1-{[2-(trimethylsilyl)ethoxy]methyl}-2,2',3,3'-tetrahydro-1H,1'H-spiro[1,8-naphthyridine-4,4'-pyridine]-1'-carboxylate

Base Information

Chemical Name:benzyl 2-oxo-1-{[2-(trimethylsilyl)ethoxy]methyl}-2,2',3,3'-tetrahydro-1H,1'H-spiro[1,8-naphthyridine-4,4'-pyridine]-1'-carboxylate
CAS No.:885032-12-2
Molecular Formula:C₂₆H₃₃N₃O₄Si
Molecular Weight:479.651
Hs Code.:

Synonyms:benzyl 2-oxo-1-{[2-(trimethylsilyl)ethoxy]methyl}-2,2',3,3'-tetrahydro-1H,1'H-spiro[1,8-naphthyridine-4,4'-pyridine]-1'-carboxylate

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Chemical Property of benzyl 2-oxo-1-{[2-(trimethylsilyl)ethoxy]methyl}-2,2',3,3'-tetrahydro-1H,1'H-spiro[1,8-naphthyridine-4,4'-pyridine]-1'-carboxylate

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Technology Process of benzyl 2-oxo-1-{[2-(trimethylsilyl)ethoxy]methyl}-2,2',3,3'-tetrahydro-1H,1'H-spiro[1,8-naphthyridine-4,4'-pyridine]-1'-carboxylate

There total 1 articles about benzyl 2-oxo-1-{[2-(trimethylsilyl)ethoxy]methyl}-2,2',3,3'-tetrahydro-1H,1'H-spiro[1,8-naphthyridine-4,4'-pyridine]-1'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 883985-01-1
benzyl 4-{2-[(3-bromopyridin-2-yl){[2-(trimethylsilyl)ethoxy]methyl}amino]-2-oxoethyl}-3,6-dihydropyridine-1(2H)-carboxylate

: 885032-12-2
benzyl 2-oxo-1-{[2-(trimethylsilyl)ethoxy]methyl}-2,2',3,3'-tetrahydro-1H,1'H-spiro[1,8-naphthyridine-4,4'-pyridine]-1'-carboxylate

Guidance literature:: With bis(tri-t-butylphosphine)palladium⁽⁰⁾; N-Methyldicyclohexylamine; In 1,4-dioxane; at 50 ℃;
DOI:10.1016/j.bmcl.2009.09.066

Reference yield: 95.0%

: 885032-12-2
benzyl 2-oxo-1-{[2-(trimethylsilyl)ethoxy]methyl}-2,2',3,3'-tetrahydro-1H,1'H-spiro[1,8-naphthyridine-4,4'-pyridine]-1'-carboxylate

: 1202006-12-9
C₂₀H₁₉N₃O₃

Guidance literature:: benzyl 2-oxo-1-{[2-(trimethylsilyl)ethoxy]methyl}-2,2',3,3'-tetrahydro-1H,1'H-spiro[1,8-naphthyridine-4,4'-pyridine]-1'-carboxylate; With trifluoroacetic acid;

With ethylenediamine; In dichloromethane;
DOI:10.1016/j.bmcl.2009.09.066

Reference yield:

: 885032-12-2
benzyl 2-oxo-1-{[2-(trimethylsilyl)ethoxy]methyl}-2,2',3,3'-tetrahydro-1H,1'H-spiro[1,8-naphthyridine-4,4'-pyridine]-1'-carboxylate

: 883985-03-3
1H-spiro[1,8-naphthyridine-4,4'-piperidin]-2(3H)-one

Guidance literature:: benzyl 2-oxo-1-{[2-(trimethylsilyl)ethoxy]methyl}-2,2',3,3'-tetrahydro-1H,1'H-spiro[1,8-naphthyridine-4,4'-pyridine]-1'-carboxylate; With trifluoroacetic acid; In dichloromethane; at 50 - 90 ℃; for 3h;

With ethylenediamine; In dichloromethane;

With hydrogen; palladium 10% on activated carbon; In ethanol; under 760.051 Torr;