N-cyclohexyl-2-(5-methylfuran-2-yl)imidazolo[1,2-a]pyridin-3-amine

Base Information

• Chemical Name: N-cyclohexyl-2-(5-methylfuran-2-yl)imidazolo[1,2-a]pyridin-3-amine
• CAS No.: 1440522-45-1
• Molecular Formula: C₁₈H₂₁N₃O
• Molecular Weight: 295.384
• Mol file: 1440522-45-1.mol

Synonyms:N-cyclohexyl-2-(5-methylfuran-2-yl)imidazolo[1,2-a]pyridin-3-amine

Chemical Property of N-cyclohexyl-2-(5-methylfuran-2-yl)imidazolo[1,2-a]pyridin-3-amine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-cyclohexyl-2-(5-methylfuran-2-yl)imidazolo[1,2-a]pyridin-3-amine

There total 1 articles about N-cyclohexyl-2-(5-methylfuran-2-yl)imidazolo[1,2-a]pyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-aminopyridine (504-29-0) + 5-Methylfurfural (620-02-0) + Cyclohexyl isocyanide (931-53-3) → N-cyclohexyl-2-(5-methylfuran-2-yl)imidazolo[1,2-a]pyridin-3-amine (1440522-45-1)

Guidance literature:

With bismuth(III) chloride; In neat (no solvent); at 110 ℃;

DOI:10.1055/s-0032-1318221

Reference yield: 76.0%

N-cyclohexyl-2-(5-methylfuran-2-yl)imidazolo[1,2-a]pyridin-3-amine (1440522-45-1) → 5-methyl-N-(pyridin-2-yl)furan-2-carboxamide (99984-52-8) + cyclohexylamine (108-91-8,157973-60-9) + 1,3-Dicyclohexylurea (2387-23-7)

Guidance literature:

With potassium tert-butylate; copper diacetate; In m-xylene; for 8h; chemoselective reaction; Schlenk technique; Heating;

DOI:10.1021/acs.joc.9b00208

upstream raw materials:

2-aminopyridine

5-Methylfurfural

Cyclohexyl isocyanide

Downstream raw materials:

5-methyl-N-(pyridin-2-yl)furan-2-carboxamide

cyclohexylamine

1,3-Dicyclohexylurea