(1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl isobutyl carbonate

Base Information

Chemical Name:(1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl isobutyl carbonate
CAS No.:1381841-56-0
Molecular Formula:C₂₆H₃₂F₂N₆O₅S
Molecular Weight:578.64
Hs Code.:

(1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl isobutyl carbonate

Synonyms:(1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl isobutyl carbonate

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Chemical Property of (1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl isobutyl carbonate

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Technology Process of (1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl isobutyl carbonate

There total 18 articles about (1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl isobutyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₃₆F₂N₆O₅S

: 1381841-56-0
(1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl isobutyl carbonate

Guidance literature:: With iodine; In methanol; at 60 ℃; for 4h;
DOI:10.1016/j.bmcl.2012.04.050

Reference yield:

: 145783-15-9
4,6-dichloro-2-(propylsulfanyl)-5-pyrimidinamine

: 1381841-56-0
(1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl isobutyl carbonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; sodium iodide / 1,4-dioxane / 120 °C

2.1: sodium nitrite / water; acetic acid; ethyl acetate

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane

4.1: triethylamine / acetonitrile / 0.5 h / 20 °C

4.2: 2 h / 20 °C

5.1: iodine / methanol / 4 h / 60 °C

With iodine; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; sodium nitrite; In 1,4-dioxane; methanol; dichloromethane; water; acetic acid; ethyl acetate; acetonitrile;
DOI:10.1016/j.bmcl.2012.04.050

Reference yield:

: 1006614-49-8,220352-38-5,1459719-81-3
(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine

: 1381841-56-0
(1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl isobutyl carbonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane

2.1: triethylamine / acetonitrile / 0.5 h / 20 °C

2.2: 2 h / 20 °C

3.1: iodine / methanol / 4 h / 60 °C

With iodine; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2012.04.050