N-[4-chloro-2-((Z)-1,3-dithiolan-1-ylidenecarbamoyl)-6-methyl-phenyl]-5-(3-chloro-2-pyridyl)-1-(2,2,2-trifluoroethyl)pyrazole-4-carboxamide

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Chemical Name:N-[4-chloro-2-((Z)-1,3-dithiolan-1-ylidenecarbamoyl)-6-methyl-phenyl]-5-(3-chloro-2-pyridyl)-1-(2,2,2-trifluoroethyl)pyrazole-4-carboxamide
CAS No.:1423122-29-5
Molecular Formula:C₂₂H₁₈Cl₂F₃N₅O₂S₂
Molecular Weight:576.45
Hs Code.:

Synonyms:N-[4-chloro-2-((Z)-1,3-dithiolan-1-ylidenecarbamoyl)-6-methyl-phenyl]-5-(3-chloro-2-pyridyl)-1-(2,2,2-trifluoroethyl)pyrazole-4-carboxamide

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Chemical Property of N-[4-chloro-2-((Z)-1,3-dithiolan-1-ylidenecarbamoyl)-6-methyl-phenyl]-5-(3-chloro-2-pyridyl)-1-(2,2,2-trifluoroethyl)pyrazole-4-carboxamide

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Technology Process of N-[4-chloro-2-((Z)-1,3-dithiolan-1-ylidenecarbamoyl)-6-methyl-phenyl]-5-(3-chloro-2-pyridyl)-1-(2,2,2-trifluoroethyl)pyrazole-4-carboxamide

There total 7 articles about N-[4-chloro-2-((Z)-1,3-dithiolan-1-ylidenecarbamoyl)-6-methyl-phenyl]-5-(3-chloro-2-pyridyl)-1-(2,2,2-trifluoroethyl)pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1423036-79-6
6-chloro-2-[5-(3-chloropyridin-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl]-8-methylbenzo[d][1,3]oxazin-4-one

: 1,3-dithiolan-1-ium-1-amine-2,4,6-trimethylbenzenesulfonate

: 1423122-29-5
N-[4-chloro-2-((Z)-1,3-dithiolan-1-ylidenecarbamoyl)-6-methyl-phenyl]-5-(3-chloro-2-pyridyl)-1-(2,2,2-trifluoroethyl)pyrazole-4-carboxamide

Guidance literature:: With potassium tert-butylate; In dichloromethane; at 20 ℃;

Reference yield:

: 128073-02-9
3-chloropyridine-2-carbonyl chloride

: 1423122-29-5
N-[4-chloro-2-((Z)-1,3-dithiolan-1-ylidenecarbamoyl)-6-methyl-phenyl]-5-(3-chloro-2-pyridyl)-1-(2,2,2-trifluoroethyl)pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; magnesium chloride / acetonitrile / 3 h / 20 °C

1.2: 0 - 20 °C

2.1: 2 h / Reflux

3.1: ethanol / 2 h / Reflux

4.1: lithium hydroxide; water / tetrahydrofuran / Reflux

5.1: triethylamine; methanesulfonyl chloride / acetonitrile / 0 °C

5.2: 0 - 20 °C

6.1: potassium tert-butylate / dichloromethane / 20 °C

With potassium tert-butylate; water; methanesulfonyl chloride; triethylamine; magnesium chloride; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 57266-69-0
3-chloropyridine-2-carboxylic acid

: 1423122-29-5
N-[4-chloro-2-((Z)-1,3-dithiolan-1-ylidenecarbamoyl)-6-methyl-phenyl]-5-(3-chloro-2-pyridyl)-1-(2,2,2-trifluoroethyl)pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 1 h / Reflux

2.1: triethylamine; magnesium chloride / acetonitrile / 3 h / 20 °C

2.2: 0 - 20 °C

3.1: 2 h / Reflux

4.1: ethanol / 2 h / Reflux

5.1: lithium hydroxide; water / tetrahydrofuran / Reflux

6.1: triethylamine; methanesulfonyl chloride / acetonitrile / 0 °C

6.2: 0 - 20 °C

7.1: potassium tert-butylate / dichloromethane / 20 °C

With thionyl chloride; potassium tert-butylate; water; methanesulfonyl chloride; triethylamine; N,N-dimethyl-formamide; magnesium chloride; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; toluene; acetonitrile;