3-Chloropicolinic acid

Base Information

• Chemical Name: 3-Chloropicolinic acid
• CAS No.: 57266-69-0
• Molecular Formula: C6H4ClNO2
• Molecular Weight: 157.556
• Hs Code.: 29333990
• European Community (EC) Number: 637-210-2
• DSSTox Substance ID: DTXSID00356458
• Nikkaji Number: J1.773.673F
• Wikidata: Q72457758
• Mol file: 57266-69-0.mol

Synonyms:3-Chloropicolinic acid;57266-69-0;3-Chloropyridine-2-carboxylic acid;3-Chloro-2-pyridinecarboxylic Acid;2-Pyridinecarboxylic acid, 3-chloro-;MFCD01646325;chloropicolinic acid;3-Chloropicolinicacid;AC-907/34123052;2-METHYLDIPHENYLSULFIDE;SCHEMBL209954;3-CHLORO-2-PICOLINICACID;DTXSID00356458;3-chloropyridin-2-carboxylic acid;XTMUXJBJCMRWPG-UHFFFAOYSA-N;3-chloro-pyridin-2-carboxylic acid;3-chloro-pyridine-2-carboxylic acid;BBL102914;CL0142;STL556723;AKOS005198945;AC-7508;CS-W002811;FS-1267;PB30690;SY007503;3-Chloropyridine-2-carboxylic acid, 97%;A8168;AM20061335;C2342;FT-0645396;EN300-93155;J-512326;F1926-0037;Z1203161828

Chemical Property of 3-Chloropicolinic acid

Chemical Property:

• Appearance/Colour: off-white solid
• Melting Point: 148-150 °C
• Boiling Point: 297.6 °C at 760 mmHg
• PKA: 2.41±0.10(Predicted)
• Flash Point: 133.8 °C
• PSA: 50.19000
• Density: 1.47 g/cm³
• LogP: 1.43320
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Acetonitrile (Slightly), Methanol (Slightly)
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 156.9930561
• Heavy Atom Count: 10
• Complexity: 140

Purity/Quality:

98%, ^*data from raw suppliers

3-ChloropicolinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)C(=O)O)Cl
• Uses: 3-Chloropicolinic Acid (cas# 57266-69-0) is a compound useful in organic synthesis. 3-Chloropyridine-2-carboxylic acid is a useful synthetic intermediate.

Technology Process of 3-Chloropicolinic acid

There total 10 articles about 3-Chloropicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

lithium; 3-chloro-pyridine-2-carboxylate → 3-chloropyridine-2-carboxylic acid (57266-69-0)

Guidance literature:

With Amberlyst(R) IR-200; In methanol; at 20 ℃; for 0.25h;

DOI:10.1016/S0040-4020(02)00673-7

Reference yield: 45.0%

3-chloro-2-methylpyridine (72093-03-9) → 3-chloropyridine-2-carboxylic acid (57266-69-0)

Guidance literature:

With potassium permanganate; for 21.5h; Heating;

DOI:10.1021/jm970529f

Reference yield:

3-chloro-2-cyanopyridine (38180-46-0) → 3-chloropyridine-2-carboxylic acid (57266-69-0)

Guidance literature:

In methanol; sodium hydroxide; dichloromethane;

upstream raw materials:

3-amino-pyridine-2-carboxylic acid

3-chloropicolinanilide

3-chloro-2-methylpyridine

2-Picolinic acid

Downstream raw materials:

3-Chloropyridine

3-chloronicotinamide

3-chloropyridine-2-carbonyl chloride

3-chloro-2-hydroxy-methyl-pyridine