Benzhydrol-d10

Base Information

• Chemical Name: Benzhydrol-d10
• CAS No.: 74563-01-2
• Molecular Formula: C₁₃H₁₂O
• Molecular Weight: 194.158
• Mol file: 74563-01-2.mol

Synonyms:benzhydrol-d₁₀

Chemical Property of Benzhydrol-d10

Chemical Property:

• Solubility.: Chloroform, Dichloromethane, Ethyl Acetate, Methanol,

Purity/Quality:

98%2H ^*data from raw suppliers

Benzhydrol-d10 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Intermediate in the preparation of labelled Modafinil (M482500).

Technology Process of Benzhydrol-d10

There total 5 articles about Benzhydrol-d10 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(2H10)benzophenone (22583-75-1) → benzhydrol-d10 (74563-01-2)

Guidance literature:

With pyridine; hydrogen; palladium on activated charcoal; In 1,4-dioxane;

DOI:10.1021/jo01310a031

Reference yield:

benzene-d6 (1076-43-3) → benzhydrol-d10 (74563-01-2)

Guidance literature:

Multi-step reaction with 2 steps

1: AlCl₃

2: 70 percent / pyridine, H₂ / palladium/carbon / dioxane

With pyridine; aluminium trichloride; hydrogen; palladium on activated charcoal; In 1,4-dioxane;

DOI:10.1021/jo01310a031

Reference yield:

2,3,4,5,6-pentadeuteriobenzaldehyde (14132-51-5) + bromobenzene-d5 (4165-57-5) → benzhydrol-d10 (74563-01-2)

Guidance literature:

bromobenzene-d5; With iodine; magnesium; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

2,3,4,5,6-pentadeuteriobenzaldehyde; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

DOI:10.1002/chem.201404987

upstream raw materials:

(2H₁₀)benzophenone

benzene-d6

bromobenzene-d5

2,3,4,5,6-pentadeuteriobenzaldehyde

Downstream raw materials:

diphenylacetonitrile-d₁₀

Refernces

• 1、 Pri-Bar, Ilan,Buchman, Ouri,Schumann, Hebert,Kroth, Heinz J.,Blum, Jochanan. "Transformation of Carbinols by RuCl2(PPh3)3 and by Some Other Transition-Metal Catalysts". . p. 4418 - 4428. Retrieved 2007/10/02.