N⁵-(N-carbobenzyloxy-L-threonyl)-N¹,N⁹-bis[2,3-bis(benzyloxy)benzoyl]homospermidine

Base Information

• Chemical Name: N⁵-(N-carbobenzyloxy-L-threonyl)-N¹,N⁹-bis[2,3-bis(benzyloxy)benzoyl]homospermidine
• CAS No.: 357628-48-9
• Molecular Formula: C₆₂H₆₆N₄O₁₀
• Molecular Weight: 1027.23
• Mol file: 357628-48-9.mol

Synonyms:N⁵-(N-carbobenzyloxy-L-threonyl)-N¹,N⁹-bis[2,3-bis(benzyloxy)benzoyl]homospermidine

Chemical Property of N⁵-(N-carbobenzyloxy-L-threonyl)-N¹,N⁹-bis[2,3-bis(benzyloxy)benzoyl]homospermidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁵-(N-carbobenzyloxy-L-threonyl)-N¹,N⁹-bis[2,3-bis(benzyloxy)benzoyl]homospermidine

There total 4 articles about N⁵-(N-carbobenzyloxy-L-threonyl)-N¹,N⁹-bis[2,3-bis(benzyloxy)benzoyl]homospermidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

Benzyloxycarbonyl-L-threonin-N-hydroxysuccinimidester (76401-90-6) + N1,N9-bis[2,3-bis(benzyloxy)benzoyl]homospermidine (357628-43-4) → N5-(N-carbobenzyloxy-L-threonyl)-N1,N9-bis[2,3-bis(benzyloxy)benzoyl]homospermidine (357628-48-9)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1021/jm010019s

Reference yield:

sym-homospermidine (4427-76-3) → N5-(N-carbobenzyloxy-L-threonyl)-N1,N9-bis[2,3-bis(benzyloxy)benzoyl]homospermidine (357628-48-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,1-carbonyldiimidazole / CH₂Cl₂ / 1 h / 20 °C

1.2: 64 percent / CH₂Cl₂

2.1: 77 percent / Et₃N / CH₂Cl₂

With triethylamine; 1,1'-carbonyldiimidazole; In dichloromethane;

DOI:10.1021/jm010019s

Reference yield:

N-benzyloxycarbonyl-L-treonine (19728-63-3) → N5-(N-carbobenzyloxy-L-threonyl)-N1,N9-bis[2,3-bis(benzyloxy)benzoyl]homospermidine (357628-48-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,3-dicyclohexylcarbodiimide / CH₂Cl₂ / 18 h / 20 °C

2: 77 percent / Et₃N / CH₂Cl₂

With triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1021/jm010019s

upstream raw materials:

Benzyloxycarbonyl-L-threonin-N-hydroxysuccinimidester

N¹,N⁹-bis[2,3-bis(benzyloxy)benzoyl]homospermidine

sym-homospermidine

N-benzyloxycarbonyl-L-treonine