Z-THR-OSU

Base Information

• Chemical Name: Z-THR-OSU
• CAS No.: 76401-90-6
• Molecular Formula: C16H18 N2 O7
• Molecular Weight: 350.32
• Mol file: 76401-90-6.mol

Synonyms:Carbamicacid, [1-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]-2-hydroxypropyl]-,phenylmethyl ester, [R-(R*,S*)]-

Chemical Property of Z-THR-OSU

Chemical Property:

• Refractive Index: 1.592
• PKA: 10.39±0.46(Predicted)
• PSA: 122.24000
• Density: 1.41±0.1 g/cm3(Predicted)
• LogP: 0.59820
• Storage Temp.: -15°C

Purity/Quality:

98%min ^*data from raw suppliers

Z-L-threonine N-hydroxysuccinimide ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-THR-OSU

There total 1 articles about Z-THR-OSU which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + N-benzyloxycarbonyl-L-treonine (19728-63-3) → Benzyloxycarbonyl-L-threonin-N-hydroxysuccinimidester (76401-90-6)

Guidance literature:

With N-ethylmorpholine;; benzotriazol-1-ol; In dichloromethane; 1) 0 deg C, 2 h, 2) overnight, r.t.;

Reference yield: 89.0%

L-aspartic acid β-tert-butyl ester α-methyl ester (39895-10-8,84907-98-2) + Benzyloxycarbonyl-L-threonin-N-hydroxysuccinimidester (76401-90-6) → Z-Thr-Asp(OBut)-OMe (144332-93-4)

Guidance literature:

With 4-methyl-morpholine; In N,N-dimethyl-formamide; for 4h; Ambient temperature;

DOI:10.1016/0223-5234(92)90151-P

Reference yield: 77.0%

Benzyloxycarbonyl-L-threonin-N-hydroxysuccinimidester (76401-90-6) + N1,N9-bis[2,3-bis(benzyloxy)benzoyl]homospermidine (357628-43-4) → N5-(N-carbobenzyloxy-L-threonyl)-N1,N9-bis[2,3-bis(benzyloxy)benzoyl]homospermidine (357628-48-9)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1021/jm010019s

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

N-benzyloxycarbonyl-L-treonine

Downstream raw materials:

Z-Thr-Asp(OBu^t)-OMe

Z-Thr-Asn-Tyr-Thr-Asp(OBu^t)-OMe

Z-Thr-Thr-Asn-Tyr-Thr-Asp(OBu^t)-OMe

Z-Thr-Thr-Asn-Tyr-Thr-OBzl