2-diazo-3-phenylpropionic acid 3-phenylprop-2-ynyl ester

Base Information

Chemical Name:2-diazo-3-phenylpropionic acid 3-phenylprop-2-ynyl ester
CAS No.:187337-16-2
Molecular Formula:C₁₈H₁₄N₂O₂
Molecular Weight:290.321
Hs Code.:

Synonyms:2-diazo-3-phenylpropionic acid 3-phenylprop-2-ynyl ester

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Chemical Property of 2-diazo-3-phenylpropionic acid 3-phenylprop-2-ynyl ester

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Technology Process of 2-diazo-3-phenylpropionic acid 3-phenylprop-2-ynyl ester

There total 3 articles about 2-diazo-3-phenylpropionic acid 3-phenylprop-2-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 187337-12-8
2-benzyl-3-oxobutyric acid 3-phenylprop-2-ynyl

: 187337-16-2
2-diazo-3-phenylpropionic acid 3-phenylprop-2-ynyl ester

Guidance literature:: With p-nitrobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 ℃; for 0.166667h;
DOI:10.1021/jo991938h

Reference yield:

: 1504-58-1
3-Phenyl-2-propyn-1-ol

: 187337-16-2
2-diazo-3-phenylpropionic acid 3-phenylprop-2-ynyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 92 percent / xylene / 2 h / 140 °C

2.1: NaH / tetrahydrofuran / 0.5 h / 25 °C

2.2: 91 percent / tetrahydrofuran / 4 h / 60 °C

3.1: 72 percent / p-nitrobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 0.17 h / 0 °C

With p-nitrobenzenesulfonyl azide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; xylene; 1.1: Ring cleavage / 2.1: deprotonation / 2.2: Alkylation / 3.1: Diazotization;
DOI:10.1021/jo991938h

Reference yield:

: 57727-97-6
3-oxobutyric acid 3-phenylprop-2-ynyl ester

: 187337-16-2
2-diazo-3-phenylpropionic acid 3-phenylprop-2-ynyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 0.5 h / 25 °C

1.2: 91 percent / tetrahydrofuran / 4 h / 60 °C

2.1: 72 percent / p-nitrobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 0.17 h / 0 °C

With p-nitrobenzenesulfonyl azide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; 1.1: deprotonation / 1.2: Alkylation / 2.1: Diazotization;
DOI:10.1021/jo991938h