1-(5-chloro-2-nitro-benzenesulfonyl)-4-hydroxymethyl-1H-pyrrole-2-carboxylic acid isopropyl ester

Base Information

Chemical Name:1-(5-chloro-2-nitro-benzenesulfonyl)-4-hydroxymethyl-1H-pyrrole-2-carboxylic acid isopropyl ester
CAS No.:273382-26-6
Molecular Formula:C₁₅H₁₅ClN₂O₇S
Molecular Weight:402.812
Hs Code.:

1-(5-chloro-2-nitro-benzenesulfonyl)-4-hydroxymethyl-1<i>H</i>-pyrrole-2-carboxylic acid isopropyl ester

Synonyms:1-(5-chloro-2-nitro-benzenesulfonyl)-4-hydroxymethyl-1H-pyrrole-2-carboxylic acid isopropyl ester

Suppliers and Price of 1-(5-chloro-2-nitro-benzenesulfonyl)-4-hydroxymethyl-1H-pyrrole-2-carboxylic acid isopropyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(5-chloro-2-nitro-benzenesulfonyl)-4-hydroxymethyl-1H-pyrrole-2-carboxylic acid isopropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(5-chloro-2-nitro-benzenesulfonyl)-4-hydroxymethyl-1H-pyrrole-2-carboxylic acid isopropyl ester

There total 4 articles about 1-(5-chloro-2-nitro-benzenesulfonyl)-4-hydroxymethyl-1H-pyrrole-2-carboxylic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 273382-23-3
1-(5-chloro-2-nitro-benzenesulfonyl)-4-formyl-1H-pyrrole-2-carboxylic acid isopropyl ester

: 273382-26-6
1-(5-chloro-2-nitro-benzenesulfonyl)-4-hydroxymethyl-1H-pyrrole-2-carboxylic acid isopropyl ester

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; water; for 2h; Heating;
DOI:10.1021/jm9901125

Reference yield:

: 21792-87-0
5-chloro-2-nitrobenzenesulfonyl chloride

: 273382-26-6
1-(5-chloro-2-nitro-benzenesulfonyl)-4-hydroxymethyl-1H-pyrrole-2-carboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / 18-crown-6; t-BuOK

2: 69 percent / sodium borohydride / tetrahydrofuran; H₂O / 2 h / Heating

With sodium tetrahydroborate; 18-crown-6 ether; potassium tert-butylate; In tetrahydrofuran; water; 1: phase-transfer condensation / 2: Reduction;
DOI:10.1021/jm9901125

Reference yield:

: 35889-88-4
propan-2-yl 1H-pyrrole-2-carboxylate

: 273382-26-6
1-(5-chloro-2-nitro-benzenesulfonyl)-4-hydroxymethyl-1H-pyrrole-2-carboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / AlCl₃ / 1,2-dichloro-ethane / -30 - 0 °C

2: 70 percent / 18-crown-6; t-BuOK

3: 69 percent / sodium borohydride / tetrahydrofuran; H₂O / 2 h / Heating

With sodium tetrahydroborate; aluminium trichloride; 18-crown-6 ether; potassium tert-butylate; In tetrahydrofuran; water; 1,2-dichloro-ethane; 1: Formylation / 2: phase-transfer condensation / 3: Reduction;
DOI:10.1021/jm9901125