3-Benzyloxymethyl-1-[(2R,3S,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-oxo-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:3-Benzyloxymethyl-1-[(2R,3S,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-oxo-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione
CAS No.:186839-92-9
Molecular Formula:C₂₉H₄₆N₂O₇Si₂
Molecular Weight:590.864
Hs Code.:

3-Benzyloxymethyl-1-[(2R,3S,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-oxo-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Synonyms:3-Benzyloxymethyl-1-[(2R,3S,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-oxo-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

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Chemical Property of 3-Benzyloxymethyl-1-[(2R,3S,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-oxo-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

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Technology Process of 3-Benzyloxymethyl-1-[(2R,3S,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-oxo-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

There total 5 articles about 3-Benzyloxymethyl-1-[(2R,3S,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-oxo-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 186839-91-8
3-Benzyloxymethyl-1-[(2R,3R,4R,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

: 186839-92-9
3-Benzyloxymethyl-1-[(2R,3S,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-oxo-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: With pyridine; chromium(VI) oxide; molecular sieve; acetic anhydride; In dichloromethane; for 0.5h; Ambient temperature;
DOI:10.1021/jo961665f

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 186839-92-9
3-Benzyloxymethyl-1-[(2R,3S,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-oxo-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / DBU / dimethylformamide / 0.5 h / 0 °C

2: 89 percent / AgNO₃, Py / tetrahydrofuran / 24 h / Ambient temperature

3: 80 percent / CrO₃, molecular sieves, Py, Ac₂O / CH₂Cl₂ / 0.5 h / Ambient temperature

With pyridine; chromium(VI) oxide; molecular sieve; acetic anhydride; silver nitrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo961665f

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 186839-92-9
3-Benzyloxymethyl-1-[(2R,3S,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-oxo-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / AgNO₃, Py / tetrahydrofuran / 24 h / Ambient temperature

2: 80 percent / CrO₃, molecular sieves, Py, Ac₂O / CH₂Cl₂ / 0.5 h / Ambient temperature

With pyridine; chromium(VI) oxide; molecular sieve; acetic anhydride; silver nitrate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo961665f