6β-(benzoylformamido)-17-(cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan

Base Information

Chemical Name:6β-(benzoylformamido)-17-(cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan
CAS No.:91409-47-1
Molecular Formula:C₂₈H₃₀N₂O₅
Molecular Weight:474.557
Hs Code.:

Synonyms:6β-(benzoylformamido)-17-(cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6β-(benzoylformamido)-17-(cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan

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Technology Process of 6β-(benzoylformamido)-17-(cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan

There total 2 articles about 6β-(benzoylformamido)-17-(cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 25726-04-9
phenylglyoxylyl chloride

: 67025-97-2
6β-naltrexamine

: 91409-47-1
6β-(benzoylformamido)-17-(cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; Yield given;
DOI:10.1021/jm00376a018

Reference yield:

: 611-73-4
Benzoylformic acid

: 91409-47-1
6β-(benzoylformamido)-17-(cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Na₂CO₃, 2.) oxalyl chloride / 2.) THF, overnight

2: Et₃N / tetrahydrofuran / 0 - 20 °C

With oxalyl dichloride; sodium carbonate; triethylamine; In tetrahydrofuran;
DOI:10.1021/jm00376a018