2-methylthio-3H-4-(p-methylphenyl)-7-<(p-methyl)phenoxy>-1,5-benzodiazepine

Base Information

• Chemical Name: 2-methylthio-3H-4-(p-methylphenyl)-7-<(p-methyl)phenoxy>-1,5-benzodiazepine
• CAS No.: 243142-73-6
• Molecular Formula: C₂₄H₂₂N₂OS
• Molecular Weight: 386.517
• Mol file: 243142-73-6.mol

Synonyms:2-methylthio-3H-4-(p-methylphenyl)-7-<(p-methyl)phenoxy>-1,5-benzodiazepine

Chemical Property of 2-methylthio-3H-4-(p-methylphenyl)-7-<(p-methyl)phenoxy>-1,5-benzodiazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methylthio-3H-4-(p-methylphenyl)-7-<(p-methyl)phenoxy>-1,5-benzodiazepine

There total 4 articles about 2-methylthio-3H-4-(p-methylphenyl)-7-<(p-methyl)phenoxy>-1,5-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2,3-dihydro-4-(p-methylphenyl)-7-<(p-methyl)phenoxy>-1H-1,5-benzodiazepine-2-thione (193539-75-2) + methyl iodide (74-88-4) → 2-methylthio-3H-4-(p-methylphenyl)-7-<(p-methyl)phenoxy>-1,5-benzodiazepine (243142-73-6)

Guidance literature:

2,3-dihydro-4-(p-methylphenyl)-7-<(p-methyl)phenoxy>-1H-1,5-benzodiazepine-2-thione; With sodium hydride; In o-xylene; for 1h; Heating;

methyl iodide; for 4h; Heating;

DOI:10.1002/jhet.5570390633

Reference yield:

3,4-diamino-phenyl-[(p-methyl)phenyl]ether (43156-14-5) → 2-methylthio-3H-4-(p-methylphenyl)-7-<(p-methyl)phenoxy>-1,5-benzodiazepine (243142-73-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: o-xylene / 8 h / Heating

2.1: sodium hydride / o-xylene / 1 h / Heating

2.2: 94 percent / 4 h / Heating

With sodium hydride; In o-xylene;

DOI:10.1002/jhet.5570390633

Reference yield:

3,3-dimercapto-1-(p-methylphenyl)-2-propen-1-one (50850-01-6) → 2-methylthio-3H-4-(p-methylphenyl)-7-<(p-methyl)phenoxy>-1,5-benzodiazepine (243142-73-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: o-xylene / 8 h / Heating

2.1: sodium hydride / o-xylene / 1 h / Heating

2.2: 94 percent / 4 h / Heating

With sodium hydride; In o-xylene;

DOI:10.1002/jhet.5570390633

upstream raw materials:

2,3-dihydro-4-(p-methylphenyl)-7-<(p-methyl)phenoxy>-1H-1,5-benzodiazepine-2-thione

methyl iodide

3,3-dimercapto-1-(p-methylphenyl)-2-propen-1-one

3,4-diamino-phenyl-[(p-methyl)phenyl]ether