4-chloro-2-(methylthio)-7-<<1,3-bis(benzyloxy)-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidine

Base Information

• Chemical Name: 4-chloro-2-(methylthio)-7-<<1,3-bis(benzyloxy)-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidine
• CAS No.: 118043-76-8
• Molecular Formula: C₂₅H₂₆ClN₃O₃S
• Molecular Weight: 484.019

Synonyms:4-chloro-2-(methylthio)-7-<<1,3-bis(benzyloxy)-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidine

Chemical Property of 4-chloro-2-(methylthio)-7-<<1,3-bis(benzyloxy)-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidine

Chemical Property:

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Technology Process of 4-chloro-2-(methylthio)-7-<<1,3-bis(benzyloxy)-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidine

There total 1 articles about 4-chloro-2-(methylthio)-7-<<1,3-bis(benzyloxy)-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-dibenzyloxy-2-(chloromethoxy)propane (74564-16-2) + 2-(methylthio)-4-chloropyrrolo<2,3-d>pyrimidine (57564-94-0) → 4-chloro-2-(methylthio)-7-<<1,3-bis(benzyloxy)-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidine (118043-76-8)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 2.) DMF, room temperature, 20 h;

DOI:10.1021/jm00122a019

Reference yield:

4-chloro-2-(methylthio)-7-<<1,3-bis(benzyloxy)-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidine (118043-76-8) → 4-amino-7-<<1,3-bis(benzyloxy)-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidine (118043-77-9)

Guidance literature:

Multi-step reaction with 2 steps

1: methanolic ammonia / 10 h / 130 °C

2: 15percent aq. NH₄OH / Raney Ni / ethanol / 1.5 h / Heating

With ammonium hydroxide; ammonia; nickel; In ethanol;

DOI:10.1021/jm00122a019

Reference yield:

4-chloro-2-(methylthio)-7-<<1,3-bis(benzyloxy)-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidine (118043-76-8) → 7-(2-Benzyloxy-1-benzyloxymethyl-ethoxymethyl)-2-methylsulfanyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine

Guidance literature:

With ammonia; at 130 ℃; for 10h;

DOI:10.1021/jm00122a019

upstream raw materials:

1,3-dibenzyloxy-2-(chloromethoxy)propane

2-(methylthio)-4-chloropyrrolo<2,3-d>pyrimidine

Downstream raw materials:

4-amino-7-<<1,3-bis(benzyloxy)-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidine

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