74564-16-2

Basic information

• Product Name: 1,1'-[[2-(Chloromethoxy)-1,3-propanediyl]bis(oxymethylene)]bisbenzene
• Synonyms: [(1,3-Bisbenzyloxy)-2-propoxy]methylchloride;1,1'-[[2-(Chloromethoxy)-1,3-propanediyl]bis(oxymethylene)]bisbenzene;1,3-Dibenzyloxy-2-(chloromethoxy)propane
• CAS NO: 74564-16-2
• Molecular Formula: C₁₈H₂₁ClO₃
• Molecular Weight: 320.81054
• Mol File: 74564-16-2.mol

Chemical Properties

• Boiling Point: 437.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.146
• CAS DataBase Reference: 1,1'-[[2-(Chloromethoxy)-1,3-propanediyl]bis(oxymethylene)]bisbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1'-[[2-(Chloromethoxy)-1,3-propanediyl]bis(oxymethylene)]bisbenzene(74564-16-2)
• EPA Substance Registry System: 1,1'-[[2-(Chloromethoxy)-1,3-propanediyl]bis(oxymethylene)]bisbenzene(74564-16-2)

Safety Data

• Hazardous Substances Data: 74564-16-2(Hazardous Substances Data)

Usage

Type of compound

Bisphenol

Common uses

Production of polycarbonate plastics and epoxy resins

Structural composition

Two benzene rings linked by an ether bridge, with two chloromethoxy groups and an ethyl bridge connecting the benzene rings

Properties

Ability to form strong and durable polymers

Applications

Manufacturing of consumer products such as water bottles, food containers, and electronic devices

Health concerns

Potential endocrine disruptor and possible leaching from plastic products into food and beverages

Upstream product

• 50-00-0 formaldehyd 
• 6972-79-8 dibenzyl glycerol 
• 107-06-2 1,2-dichloro-ethane 
• 20194-18-7 sodium phenyl-methanolate 
• 100-51-6 benzyl alcohol 
• 112474-97-2 methyl 2-benzyloxy-1-benzyloxymethylethoxyacetate 

Downstream Products

• 93503-26-5 1-((1,3-bis(benzyloxy)-2-propoxy)methyl)-2-thiouracil 
• 84222-48-0 N²-acetyl-7-<<1,3-bis(benzyloxy)-2-propoxy>methyl>guanine 
• 82410-30-8 N²-acetyl-9-<<1,3-bis(benzyloxy)-2-propoxy>methyl>guanine 
• 128059-89-2 1-<(2-benzyloxy-1-benzyloxymethylethoxy)methyl>-4(5H)-oxopyrazolo<3,4-d>pyrimidine 
• 84222-49-1 7-[(1,3-dibenzyloxy-2-propoxy)methyl]guanine 
• 82410-31-9 9-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>guanine 
• 82410-31-9 9-<<2-(benzyloxy)-1-<(benzyloxy)methyl>ethoxy>methyl>guanine 
• 84245-11-4 1-benzyloxy-3-benzyloxy-2acetyloxymethoxypropane 
• 118043-76-8 4-chloro-2-(methylthio)-7-<<1,3-bis(benzyloxy)-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidine 
• 90330-23-7 1-<(2-benzoxy-1-(benzoxymethyl)ethoxy)methyl>-1,2,4-triazole-3-carboxylic acid methyl ester 
• 90330-24-8 1-<(2-benzoxy-1-(benzoxymethyl)ethoxy)methyl>-1,2,4-triazole-5-carboxylic acid methyl ester 
• 101924-17-8 2-methylthio-4-methoxy-7-<(1,3-dibenzyloxy-2-propoxy)methyl>pyrrolo<2,3-d>pyrimidine 
• 82410-25-1 1-[[2-benzyloxy-1-(benzyloxymethyl)-ethoxy]methyl]-5-fluorouracil 
• 173461-08-0 1-(2-Benzyloxy-1-benzyloxymethyl-ethoxymethyl)-2,4,5-trichloro-1H-benzoimidazole 

Relevant articles and documents

PREVENTION AND TREATMENT OF CANCER AND OTHER DISEASES

Nucleoside chemical compounds, which interact with specific structures of deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) are disclosed. The compounds interfere with the activities of telomerase and reverse transcriptase, and are useful as antivirals, antibacterials and anticancer agents. Methods of treating or preventing cancers in patients involving administration of a therapeutically effective amount of a composition having an inhibitor or antagonist of the reverse transcriptases (RTs) expressed in cells of the patients are also disclosed. Method of using nucleoside analogs and other inhibitors of RTs in conjunction with DNA damaging agents such as genotoxic agents or radiation or photodynamic therapy or combinations these for the treatment of various cancers are also disclosed.

An Improved Total Synthesis of PET HSV-tk Gene Expression Imaging Agent 9-[(3-[18F]Fluoro-1-hydroxy-2-propoxy)methyl]guanine ([ 18F]FHPG)

An improved total synthesis of [18F]FHPG starting from 1,3-dibenzyloxy-2-propanol and guanine has been developed. [18F]FHPG was prepared by nucleophilic substitution of the appropriate precursor with [18F]KF/ Kryptofix 2.2.2 followed by a quick deprotection reaction and purification with a simplified Silica Sep-Pak solid-phase extraction (SPE) method in 10-15% radiochemical yield, and 70 min synthesis time from end of bombardment (EOB).

Novel radiosynthesis of PET HSV-tk gene reporter probes [ 18F]FHPG and [18F]FHBG employing dual Sep-Pak SPE techniques

Positron emission tomography (PET) herpes simplex virus thymidine kinase (HSV-tk) gene reporter probes 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy) methyl]guanine ([18F]FHPG) and 9-(4-[18F]fluoro-3- hydroxymethylbutyl)guanine ([18F]FHBG) were prepared by nucleophilic substitution of the appropriate tosylated precursors with [18F]KF/ Kryptofix 2.2.2 followed by a quick deprotection reaction and purification with a simplified dual Silica Sep-Pak solid-phase extraction (SPE) method in 15-30% radiochemical yield.

Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent

Compounds useful as antiviral agents are defined by the following formula: STR1 and the pharmaceutically acceptable acid addition salts thereof wherein R1 is hydrogen or --C(O)R7 wherein R7 is hydrogen, alkyl of one to nineteen carbon atoms, hydroxyalkyl of one to eight carbon atoms, alkoxyalkyl of two to nine carbon atoms, alkenyl of two to nineteen carbon atoms, phenyl, 1-adamantyl or 2-carboxyethyl and the pharmaceutically acceptable alkali metal salts thereof; R2 is --C(O)R7 wherein R7 is as defined above; R3 is hydrogen, halo, thio, lower alkylthio of one to six carbon atoms, azido, NR9 R10 wherein R9 and R10 are independently hydrogen or lower alkyl of one to six carbon atoms or --NHC(O)R8 wherein R8 is hydrogen, alkyl of one to nineteen carbon atoms or 1-adamantyl; and (a) R6 is hydrogen, halo, lower alkoxy of one to six carbon atoms, azido, thio, lower alkylthio of one to six carbon atoms, --NR9 R10 wherein R9 and R10 are as defined above or --NHC(O)R8 wherein R8 is as defined above and R4 together with R5 is a bond; or (b) R5 together with R6 is a keto group and R4 is hydrogen.

SYNTHESIS AND ANTIVIRAL ACTIVITY OF 1,2,3-TRIAZOLE AND 8-AZAPURINE DERIVATIVES BEARING ACYCLIC SUGARS

A variety of 1,2,3-triazole and 8-azapurine derivatives bearing acyclic sugar moieties were synthesized by the reaction of acyclic sugar azides with α-cyanoacetamide, norbornadiene, and acetylene derivatives, respectively.Antiviral tests of these compound

Effect of Acyclic Pyrimidines Related to 9-guanine on Herpesviruses

A series of pyrimidines related to the potent antiherpetic agent 9-guanine (1, BW B759U), all containing the same acyclic chain, have been synthesized.Some of the compounds were derivatives of the naturally occuring bases, cytosine, uracil, and thymine; others included compounds in which the 5-position of the cytosine and uracil moieties were substituted by bromo, iodo, fluoro, methyl, and amino groups.Other variations of the cytosine derivatives were the 5-aza, 2-mercapto, 4-methylamino, 4-dimethylamino, and isocytosine congeners.A 4-aminopyrimidine adduct was also made.Antiviral testing showed that 1-cytosine (18, BW A1117U) was equivalent to the guanine analogue in the potency against human cytomegalovirus and Epstein Barr virus.Other compounds in the series were largely inactive in antiviral screening against the herpesviruses.

TWO ACYCLIC ANALOGUES OF 2-β-D-RIBOFURANOSYL THIAZOLE-4-CARBOXAMIDE (TIAZOFURIN)

Two different synthetic strategies have been elaborated for the synthesis of 2-thiazole-4-carboxamide (4) and 2-methyl>thiazole-4-carboxamide (5).

Process for preparing guanine derivatives

1-Monophosphate esters, 1,3-bisphosphate esters and cyclic phosphate esters of 9-(1,3-dihydroxy-2-propoxymethyl)guanine are useful as antiviral agents.