2-{[5-(5-{5-[bis(4-methylphenyl)amino]thiophen-2-yl}thiophen-2-yl)thiophen-2-yl]methylidene}propanedinitrile

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Chemical Name:2-{[5-(5-{5-[bis(4-methylphenyl)amino]thiophen-2-yl}thiophen-2-yl)thiophen-2-yl]methylidene}propanedinitrile
CAS No.:1256639-81-2
Molecular Formula:C₃₀H₂₁N₃S₃
Molecular Weight:519.715
Hs Code.:

Synonyms:2-{[5-(5-{5-[bis(4-methylphenyl)amino]thiophen-2-yl}thiophen-2-yl)thiophen-2-yl]methylidene}propanedinitrile

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Chemical Property of 2-{[5-(5-{5-[bis(4-methylphenyl)amino]thiophen-2-yl}thiophen-2-yl)thiophen-2-yl]methylidene}propanedinitrile

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Technology Process of 2-{[5-(5-{5-[bis(4-methylphenyl)amino]thiophen-2-yl}thiophen-2-yl)thiophen-2-yl]methylidene}propanedinitrile

There total 4 articles about 2-{[5-(5-{5-[bis(4-methylphenyl)amino]thiophen-2-yl}thiophen-2-yl)thiophen-2-yl]methylidene}propanedinitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.4%

: 1219091-34-5
5-(N,N-di-p-tolylamino)-2,5'-bithiophene-2',5-bithiophene-2-carboxaldehyde

: 109-77-3
malononitrile

: 1256639-81-2
2-{[5-(5-{5-[bis(4-methylphenyl)amino]thiophen-2-yl}thiophen-2-yl)thiophen-2-yl]methylidene}propanedinitrile

Guidance literature:: With pyridine; In chloroform; at 20 ℃;

Reference yield:

: 620-93-9
di-p-tolylamine

: 1256639-81-2
2-{[5-(5-{5-[bis(4-methylphenyl)amino]thiophen-2-yl}thiophen-2-yl)thiophen-2-yl]methylidene}propanedinitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium diacetate; tri-tert-butyl phosphine; sodium t-butanolate / o-xylene

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: bis-triphenylphosphine-palladium(II) chloride / toluene / 20 °C / Inert atmosphere; Reflux

4.1: pyridine / chloroform / 20 °C / Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; tri-tert-butyl phosphine; palladium diacetate; sodium t-butanolate; In tetrahydrofuran; chloroform; o-xylene; toluene;
DOI:10.1016/j.tet.2013.02.040

Reference yield:

: 89331-93-1
2-[N,N-di(p-tolyl)amino]thiophene

: 1256639-81-2
2-{[5-(5-{5-[bis(4-methylphenyl)amino]thiophen-2-yl}thiophen-2-yl)thiophen-2-yl]methylidene}propanedinitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: bis-triphenylphosphine-palladium(II) chloride / toluene / 20 °C / Inert atmosphere; Reflux

3.1: pyridine / chloroform / 20 °C / Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; In tetrahydrofuran; chloroform; toluene;
DOI:10.1016/j.tet.2013.02.040