(R)-2-isobutyl-4-oxo-8-phenyloctanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide

Base Information

Chemical Name:(R)-2-isobutyl-4-oxo-8-phenyloctanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide
CAS No.:209664-22-2
Molecular Formula:C₂₄H₃₉NO₃
Molecular Weight:389.579
Hs Code.:

Synonyms:(R)-2-isobutyl-4-oxo-8-phenyloctanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-isobutyl-4-oxo-8-phenyloctanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide

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Technology Process of (R)-2-isobutyl-4-oxo-8-phenyloctanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide

There total 6 articles about (R)-2-isobutyl-4-oxo-8-phenyloctanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 209664-18-6
(R)-2-Isobutyl-4-oxo-8-phenyl-octanoic acid methyl ester

: 209664-22-2
(R)-2-isobutyl-4-oxo-8-phenyloctanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide

Guidance literature:: Multi-step reaction with 2 steps

1: LiOH*H₂O / methanol; H₂O / 70 - 75 °C

2: N-methylmorpholine, 1-HOBt, BOP / dimethylformamide / 0 - 23 °C

With 4-methyl-morpholine; lithium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(98)00009-1

Reference yield:

: 2270-20-4
5-Phenylpentanoic acid

: 209664-22-2
(R)-2-isobutyl-4-oxo-8-phenyloctanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 1,1'-carbonyldiimidazole / 1.) THF, 0 deg C, 0.5 h; room temperature, overnight, 2.) THF, hexane, -78 deg C, 0.5 h

2: 1.) NaH / 1.) THF, room temperature, overnight, 2.) TFA, room temperature, 3.) benzene, reflux

3: LiOH*H₂O / methanol; H₂O / 70 - 75 °C

4: N-methylmorpholine, 1-HOBt, BOP / dimethylformamide / 0 - 23 °C

With 4-methyl-morpholine; lithium hydroxide; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; 1,1'-carbonyldiimidazole; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(98)00009-1

Reference yield:

: 189030-32-8
tert-butyl 3-oxo-7-phenylheptanoate

: 209664-22-2
(R)-2-isobutyl-4-oxo-8-phenyloctanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) THF, room temperature, overnight, 2.) TFA, room temperature, 3.) benzene, reflux

2: LiOH*H₂O / methanol; H₂O / 70 - 75 °C

3: N-methylmorpholine, 1-HOBt, BOP / dimethylformamide / 0 - 23 °C

With 4-methyl-morpholine; lithium hydroxide; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(98)00009-1