[4-[1-(benzo[b]thien-2-yl)ethyl]-2-(methylthio)phenyl] trifluoromethanesulfonate

Base Information

Chemical Name:[4-[1-(benzo[b]thien-2-yl)ethyl]-2-(methylthio)phenyl] trifluoromethanesulfonate
CAS No.:212705-03-8
Molecular Formula:C₁₈H₁₅F₃O₃S₃
Molecular Weight:432.509
Hs Code.:

Synonyms:[4-[1-(benzo[b]thien-2-yl)ethyl]-2-(methylthio)phenyl] trifluoromethanesulfonate

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Chemical Property of [4-[1-(benzo[b]thien-2-yl)ethyl]-2-(methylthio)phenyl] trifluoromethanesulfonate

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Technology Process of [4-[1-(benzo[b]thien-2-yl)ethyl]-2-(methylthio)phenyl] trifluoromethanesulfonate

There total 4 articles about [4-[1-(benzo[b]thien-2-yl)ethyl]-2-(methylthio)phenyl] trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 212705-00-5
4-[1-(benzo[b]thien-2-yl)ethyl]-2-(methylthio)phenol

: 212705-03-8
[4-[1-(benzo[b]thien-2-yl)ethyl]-2-(methylthio)phenyl] trifluoromethanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at -40 - 20 ℃; for 1.25h;
DOI:10.1021/jo980537j

Reference yield:

: 51868-95-2
1-(benzo[b]thiophen-2-yl)ethanol

: 212705-03-8
[4-[1-(benzo[b]thien-2-yl)ethyl]-2-(methylthio)phenyl] trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 34.5 percent / BF₃-OEt₂ / CH₂Cl₂ / 1 h / 20 °C

2: 97 percent / triethylamine / CH₂Cl₂ / 1.25 h / -40 - 20 °C

With boron trifluoride diethyl etherate; triethylamine; In dichloromethane; 1: Friedel-Crafts alkylation / 2: Esterification;
DOI:10.1021/jo980537j

Reference yield:

: 22720-75-8
2-acetyl benzo[b]thiophene

: 212705-03-8
[4-[1-(benzo[b]thien-2-yl)ethyl]-2-(methylthio)phenyl] trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / NaBH₄ / methanol / 0.33 h / 0 °C

2: 34.5 percent / BF₃-OEt₂ / CH₂Cl₂ / 1 h / 20 °C

3: 97 percent / triethylamine / CH₂Cl₂ / 1.25 h / -40 - 20 °C

With sodium tetrahydroborate; boron trifluoride diethyl etherate; triethylamine; In methanol; dichloromethane; 1: Reduction / 2: Friedel-Crafts alkylation / 3: Esterification;
DOI:10.1021/jo980537j