3-(2,4,5-trifluorophenyl)-3-oxo-2-(ethoxymethylene)-propanoic acid ethyl ester

Base Information

Chemical Name:3-(2,4,5-trifluorophenyl)-3-oxo-2-(ethoxymethylene)-propanoic acid ethyl ester
CAS No.:104600-42-2
Molecular Formula:C₁₄H₁₃F₃O₄
Molecular Weight:302.25
Hs Code.:

Synonyms:3-(2,4,5-trifluorophenyl)-3-oxo-2-(ethoxymethylene)-propanoic acid ethyl ester

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Chemical Property of 3-(2,4,5-trifluorophenyl)-3-oxo-2-(ethoxymethylene)-propanoic acid ethyl ester

Chemical Property:

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Technology Process of 3-(2,4,5-trifluorophenyl)-3-oxo-2-(ethoxymethylene)-propanoic acid ethyl ester

There total 2 articles about 3-(2,4,5-trifluorophenyl)-3-oxo-2-(ethoxymethylene)-propanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88419-56-1
2,4,5-trifluorobenzoyl chloride

: 104600-42-2
3-(2,4,5-trifluorophenyl)-3-oxo-2-(ethoxymethylene)-propanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: MgCl₂; Et₃N / acetonitrile / 2.5 h / 20 - 25 °C

1.2: 90 percent / Et₃N / acetonitrile / 18 h / 20 °C

2.1: Ac₂O / 4 h / Heating

With acetic anhydride; triethylamine; magnesium chloride; In acetonitrile;
DOI:10.1021/jm0497895

Reference yield:

: 98349-24-7
ethyl 2,4,5-trifluorobenzoylacetate

: 122-51-0
orthoformic acid triethyl ester

: 104600-42-2
3-(2,4,5-trifluorophenyl)-3-oxo-2-(ethoxymethylene)-propanoic acid ethyl ester

Guidance literature:: With acetic anhydride; for 4h; Heating;
DOI:10.1021/jm0497895

Reference yield: 88.0%

: 6421-88-1
2-(4-aminophenoxy)ethanol

: 104600-42-2
3-(2,4,5-trifluorophenyl)-3-oxo-2-(ethoxymethylene)-propanoic acid ethyl ester

: ethyl 6,7-difluoro-1-(4-(2-hydroxyethoxy)phenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate

Guidance literature:: 2-(4-aminophenoxy)ethanol; 3-(2,4,5-trifluorophenyl)-3-oxo-2-(ethoxymethylene)-propanoic acid ethyl ester; In dimethyl sulfoxide; at 20 ℃; for 1h;

With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 1h;