1-(3-benzyloxyphenyl)-2-(4-nitrophenyl)ethane

Base Information

• Chemical Name: 1-(3-benzyloxyphenyl)-2-(4-nitrophenyl)ethane
• CAS No.: 239445-36-4
• Molecular Formula: C₂₁H₁₉NO₃
• Molecular Weight: 333.387
• Mol file: 239445-36-4.mol

Synonyms:1-(3-benzyloxyphenyl)-2-(4-nitrophenyl)ethane

Chemical Property of 1-(3-benzyloxyphenyl)-2-(4-nitrophenyl)ethane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-benzyloxyphenyl)-2-(4-nitrophenyl)ethane

There total 6 articles about 1-(3-benzyloxyphenyl)-2-(4-nitrophenyl)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl bromide (100-39-0) + 1-(3-hydroxyphenyl)-2-(4-nitrophenyl)ethane (239445-40-0) → 1-(3-benzyloxyphenyl)-2-(4-nitrophenyl)ethane (239445-36-4)

Guidance literature:

With potassium carbonate; In acetone; for 24h; Heating;

DOI:10.1021/jo990362t

Reference yield:

3-methoxybenzyl alcohol (6971-51-3) → 1-(3-benzyloxyphenyl)-2-(4-nitrophenyl)ethane (239445-36-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 98 percent / Me₃SiCl; LiBr / acetonitrile / 22 h / Heating

2.1: NaH / tetrahydrofuran / 2 h / 0 °C

2.2: 82 percent / tetrahydrofuran / 20 °C

3.1: 98 percent / aq. NaOH / Heating

4.1: 59 percent / copper chromite / quinoline / 1.5 h / 210 - 220 °C / Acid hydrolysis

5.1: 98 percent / aq. HBr / acetic acid / 3.5 h / Heating

6.1: 100 percent / K₂CO₃ / acetone / 24 h / Heating

With sodium hydroxide; chloro-trimethyl-silane; copper chromite; hydrogen bromide; sodium hydride; potassium carbonate; lithium bromide; In tetrahydrofuran; quinoline; acetic acid; acetone; acetonitrile; 1.1: Bromination / 2.1: Metallation / 2.2: Substitution / 3.1: Hydrolysis / 4.1: Decarboxylation / 5.1: Substitution / 6.1: Alkylation;

DOI:10.1021/jo990362t

Reference yield:

1-bromomethyl-3-methoxybenzene (874-98-6) → 1-(3-benzyloxyphenyl)-2-(4-nitrophenyl)ethane (239445-36-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: NaH / tetrahydrofuran / 2 h / 0 °C

1.2: 82 percent / tetrahydrofuran / 20 °C

2.1: 98 percent / aq. NaOH / Heating

3.1: 59 percent / copper chromite / quinoline / 1.5 h / 210 - 220 °C / Acid hydrolysis

4.1: 98 percent / aq. HBr / acetic acid / 3.5 h / Heating

5.1: 100 percent / K₂CO₃ / acetone / 24 h / Heating

With sodium hydroxide; copper chromite; hydrogen bromide; sodium hydride; potassium carbonate; In tetrahydrofuran; quinoline; acetic acid; acetone; 1.1: Metallation / 1.2: Substitution / 2.1: Hydrolysis / 3.1: Decarboxylation / 4.1: Substitution / 5.1: Alkylation;

DOI:10.1021/jo990362t

upstream raw materials:

benzyl bromide

1-(3-hydroxyphenyl)-2-(4-nitrophenyl)ethane

3-methoxybenzyl alcohol

1-bromomethyl-3-methoxybenzene

Downstream raw materials:

1-(3-benzyloxyphenyl)-2-(4-azidophenyl)ethane

1-(3-benzyloxyphenyl)-2-(4-aminophenyl)ethane