dimethyl N-benzylphosphoramidothionate

Base Information

• Chemical Name: dimethyl N-benzylphosphoramidothionate
• CAS No.: 130012-35-0
• Molecular Formula: C₉H₁₄NO₂PS
• Molecular Weight: 231.255
• Mol file: 130012-35-0.mol

Synonyms:dimethyl N-benzylphosphoramidothionate

Chemical Property of dimethyl N-benzylphosphoramidothionate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of dimethyl N-benzylphosphoramidothionate

There total 1 articles about dimethyl N-benzylphosphoramidothionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

dimethyl chlorothiophosphate (2524-03-0) + benzylamine (100-46-9) → dimethyl N-benzylphosphoramidothionate (130012-35-0)

Guidance literature:

With triethylamine; In dichloromethane; for 20h; Ambient temperature;

DOI:10.1021/jo00312a012

Reference yield: 62.0%

dimethyl N-benzylphosphoramidothionate (130012-35-0) → (Benzylamido)phosphorsaeure-dimethylester (74124-44-0)

Guidance literature:

With monoperoxyphthalic acid; magnesium salt; In dichloromethane; for 12h; Heating;

DOI:10.1016/S0040-4039(00)60006-0

Reference yield:

dimethyl N-benzylphosphoramidothionate (130012-35-0) → N-benzylbenzamide (1485-70-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) sodium hydride / 1.) THF, reflux, 2 h, 2.) 0 deg C to room temperature, 15-30 min.

2: CCl₄ / Heating

3: 1 M aq. HCl / tetrahydrofuran / Ambient temperature

With hydrogenchloride; sodium hydride; In tetrahydrofuran; tetrachloromethane;

DOI:10.1021/jo00312a012

upstream raw materials:

dimethyl chlorothiophosphate

benzylamine

Downstream raw materials:

dimethyl N-(3-methylbut-2-enoyl)-N-benzylphosphoramidothionate

dimethyl N-propanoyl-N-benzylphosphoramidothionate

dimethyl N-((cis-3-acetyl-2,2-dimethylcyclobutyl)-ethanoyl)-N-benzylphosphoramidothionate

(Benzylamido)phosphorsaeure-dimethylester

Refernces

• 1、 DeBruin, Kenneth E.,Boros, Eric E.. "A New Route to N-Monosubstituted Thioamides Utilizing Phosphoramidothionates as Reagents for the Thioamidation of Carboxylic Acids". . p. 6091 - 6098. Retrieved 2007/10/02.