(2S)-2-amino-N'-benzyloxy-N-[3-(trifluoromethyl)phenyl]octanediamide trifluoroacetate

Base Information

Chemical Name:(2S)-2-amino-N'-benzyloxy-N-[3-(trifluoromethyl)phenyl]octanediamide trifluoroacetate
CAS No.:1622061-15-7
Molecular Formula:C₂HF₃O₂*C₂₂H₂₆F₃N₃O₃
Molecular Weight:551.486
Hs Code.:

Synonyms:(2S)-2-amino-N'-benzyloxy-N-[3-(trifluoromethyl)phenyl]octanediamide trifluoroacetate

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Chemical Property of (2S)-2-amino-N'-benzyloxy-N-[3-(trifluoromethyl)phenyl]octanediamide trifluoroacetate

Chemical Property:

Purity/Quality:

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Technology Process of (2S)-2-amino-N'-benzyloxy-N-[3-(trifluoromethyl)phenyl]octanediamide trifluoroacetate

There total 7 articles about (2S)-2-amino-N'-benzyloxy-N-[3-(trifluoromethyl)phenyl]octanediamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl N-[(1S)-7-(benzyloxyamino)-7-oxo-1-[[3-(trifluoromethyl)phenyl]carbamoyl]heptyl]carbamate

: 76-05-1
trifluoroacetic acid

: 1622061-15-7
(2S)-2-amino-N'-benzyloxy-N-[3-(trifluoromethyl)phenyl]octanediamide trifluoroacetate

Guidance literature:: In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 1528755-75-0
methyl (7S)-7-(tert-butoxycarbonylamino)-8-oxo-8-[3-(trifluoromethyl)anilino]octanoate

: 1622061-15-7
(2S)-2-amino-N'-benzyloxy-N-[3-(trifluoromethyl)phenyl]octanediamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; methanol / 12 h / 20 °C / Inert atmosphere

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

3: dichloromethane / 0 - 20 °C / Inert atmosphere

With methanol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In dichloromethane;

Reference yield:

: 204711-97-7
(2S)-2-[(tert-butoxycarbonyl)amino]hept-6-enoic acid

: 1622061-15-7
(2S)-2-amino-N'-benzyloxy-N-[3-(trifluoromethyl)phenyl]octanediamide trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 20 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 20 °C / Inert atmosphere

3.1: hydrogen; palladium 10% on activated carbon / methanol / 750.08 Torr / Inert atmosphere

4.1: sodium hydroxide; methanol / 12 h / 20 °C / Inert atmosphere

5.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

6.1: dichloromethane / 0 - 20 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; methanol; palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane;