methyl (7S)-7-(tert-butoxycarbonylamino)-8-oxo-8-[3-(trifluoromethyl)anilino]octanoate

Base Information

Chemical Name:methyl (7S)-7-(tert-butoxycarbonylamino)-8-oxo-8-[3-(trifluoromethyl)anilino]octanoate
CAS No.:1528755-75-0
Molecular Formula:C₂₁H₂₉F₃N₂O₅
Molecular Weight:446.467
Hs Code.:

Synonyms:methyl (7S)-7-(tert-butoxycarbonylamino)-8-oxo-8-[3-(trifluoromethyl)anilino]octanoate

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Chemical Property of methyl (7S)-7-(tert-butoxycarbonylamino)-8-oxo-8-[3-(trifluoromethyl)anilino]octanoate

Chemical Property:

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Technology Process of methyl (7S)-7-(tert-butoxycarbonylamino)-8-oxo-8-[3-(trifluoromethyl)anilino]octanoate

There total 4 articles about methyl (7S)-7-(tert-butoxycarbonylamino)-8-oxo-8-[3-(trifluoromethyl)anilino]octanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1622061-12-4
methyl (E,7S)-7-(tert-butoxycarbonylamino)-8-oxo-8-[3-(trifluoromethyl)anilino]oct-2-enoate

: 1528755-75-0
methyl (7S)-7-(tert-butoxycarbonylamino)-8-oxo-8-[3-(trifluoromethyl)anilino]octanoate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; under 750.075 Torr; Inert atmosphere;

Reference yield:

: 204711-97-7
(2S)-2-[(tert-butoxycarbonyl)amino]hept-6-enoic acid

: 1528755-75-0
methyl (7S)-7-(tert-butoxycarbonylamino)-8-oxo-8-[3-(trifluoromethyl)anilino]octanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 20 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 20 °C / Inert atmosphere

3.1: hydrogen; palladium 10% on activated carbon / methanol / 750.08 Torr / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;

Reference yield:

: 98-16-8
3-trifluoromethylaniline

: 1528755-75-0
methyl (7S)-7-(tert-butoxycarbonylamino)-8-oxo-8-[3-(trifluoromethyl)anilino]octanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 20 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 20 °C / Inert atmosphere

3.1: hydrogen; palladium 10% on activated carbon / methanol / 750.08 Torr / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;