N-[2-(difluoromethyl)-4-(methyloxy)phenyl]-3-(2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)-6-methyl-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2-pyridinamine

Base Information

Chemical Name:N-[2-(difluoromethyl)-4-(methyloxy)phenyl]-3-(2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)-6-methyl-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2-pyridinamine
CAS No.:727993-13-7
Molecular Formula:C₂₈H₃₅F₂N₅O₂SSi
Molecular Weight:571.767
Hs Code.:

N-[2-(difluoromethyl)-4-(methyloxy)phenyl]-3-(2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)-6-methyl-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2-pyridinamine

Synonyms:N-[2-(difluoromethyl)-4-(methyloxy)phenyl]-3-(2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)-6-methyl-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2-pyridinamine

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Chemical Property of N-[2-(difluoromethyl)-4-(methyloxy)phenyl]-3-(2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)-6-methyl-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2-pyridinamine

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Technology Process of N-[2-(difluoromethyl)-4-(methyloxy)phenyl]-3-(2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)-6-methyl-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2-pyridinamine

There total 2 articles about N-[2-(difluoromethyl)-4-(methyloxy)phenyl]-3-(2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)-6-methyl-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2-pyridinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 727993-36-4
2-(difluoromethyl)-4-(methyloxy)aniline

: 491864-74-5
2-chloro-3-(2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)-6-methyl-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]pyridine

: 727993-13-7
N-[2-(difluoromethyl)-4-(methyloxy)phenyl]-3-(2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)-6-methyl-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2-pyridinamine

Guidance literature:: With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2-(dicyclohexylphosphino)-2'-methylbiphenyl; In 1,2-dimethoxyethane; at 100 ℃; for 0.666667h; under 3102.97 Torr; Inert atmosphere; Microwave irradiation;
DOI:10.1021/jm800743q

Reference yield:

: 727993-13-7
N-[2-(difluoromethyl)-4-(methyloxy)phenyl]-3-(2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)-6-methyl-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2-pyridinamine

Guidance literature:

Reference yield:

: 727993-13-7
N-[2-(difluoromethyl)-4-(methyloxy)phenyl]-3-(2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)-6-methyl-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2-pyridinamine

: 2-{2-{[2-(difluoromethyl)-4-(methyloxy)phenyl]amino}-6-methyl-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-3-pyridinyl}ethanol

Guidance literature:: With triethylamine tris(hydrogen fluoride); In tetrahydrofuran; at 20 ℃; for 15h; Inert atmosphere;
DOI:10.1021/jm800743q